Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Faxeladol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.49 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.49 |
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Faxeladol SCHEMBL7893759 | 1.00 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL465057 | 1.00 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL7882332 | 1.00 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL5393347 | 0.99 | SLC6A4 (0.48) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL3417844 | 0.99 | SLC6A4 (0.48) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL149508 | 0.99 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL28793358 | 0.99 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL30616185 | 0.99 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL354208 | 0.99 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL5686250 | 0.99 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245125-A1 | HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol | GRUENENTHAL GMBH (DE) | 2013-09-19 | — | — | US | claimed |
| US-8058476-B2 | Crystalline salt of hydrogen chloride and 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]phenol; inhibiting pain | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| US-20110251287-A1 | HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL (CYCLOHEX-1-YL))PHENOL | GRUENENTHAL GMBH (DE) | 2011-10-13 | — | — | US | claimed |
| US-20100076085-A1 | HCl Polymorphs of 3-((2-(Dimethylamino)methyl-(cyclohex-1-yl))phenol | GRUENENTHAL GMBH (DE) | 2010-03-25 | — | — | US | claimed |
| US-20080255242-A1 | HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL)) PHENOL | GRUENENTHAL GMBH (DE) | 2008-10-16 | — | — | US | claimed |
| EP-3241550-B1 | (1R, 2R)-3-(DIMENTHYL AMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL FOR TREATING PAINFUL INFLAMMATIONS | GRUENENTHAL GMBH (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3662904-A1 | USE OF (1R, 2R)-3-(DIMENTHYL AMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL FOR TREATING PAINFUL INFLAMMATIONS | Grünenthal GmbH (DE) | 2020-06-10 | — | — | EP | disclosed |
| EP-3241550-A1 | (1R, 2R)-3-(DIMENTHYL AMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL FOR TREATING PAINFUL INFLAMMATIONS | Grünenthal GmbH (DE) | 2017-11-08 | — | — | EP | disclosed |
| EP-1562567-B1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | GRUENENTHAL GMBH (DE) | 2017-06-14 | — | — | EP | disclosed |
| US-20130245125-A1 | HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol | GRUENENTHAL GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| US-8404749-B2 | Method of inhibiting inflammatory pain | GRUENENTHAL GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20120178809-A1 | Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof | GRUENENTHAL GMBH (DE) | 2012-07-12 | — | — | US | disclosed |
| US-20070032552-A1 | Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof | GRUENENTHAL GMBH (DE) | 2007-02-08 | — | — | US | disclosed |
| WO-2007009793-A1 | SALT OF FUMARIC ACID AND 3-(2-DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL))PHENOL AND ITS CRYSTALLINE FORMS | Grünenthal GmbH (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009792-A1 | 3-(2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL))PHENOL MALEATE AND ITS CRYSTALLINE FORMS | Grünenthal GmbH (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009794-A1 | HCl POLYMORPHS OF 3 -(2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL))PHENOL | Grünenthal GmbH (DE) | 2007-01-25 | — | — | WO | disclosed |
| US-20060258741-A1 | C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders | GRUENENTHAL GMBH | 2006-11-16 | — | — | US | disclosed |
| US-20050119349-A1 | Process for chlorinating tertiary alcohols | GRUENENTHAL GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
| US-RE37355-E1 | 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 2001-09-04 | — | — | US | disclosed |
| US-5733936-A | ANALGESICS | GRUENENTHAL GMBH (DE) | 1998-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255242-A1 | HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL)) PHENOL | HCN3, FANCI, HCN1 | SLC6A4 183/4885SLC6A2 269/4885OPRM1 17/4885 |
| US-20120178809-A1 | Salt of Dimethylaminomethyl-Phenyl-Cyclohexane and Crystalline Forms Thereof | REN, PKD1, ACMSD | SLC6A4 1254/4885SLC6A2 782/4885OPRM1 19/4885 |
| US-20100076085-A1 | HCl Polymorphs of 3-((2-(Dimethylamino)methyl-(cyclohex-1-yl))phenol | HCLS1, PAH, PEAK1 | SLC6A4 720/4885SLC6A2 557/4885OPRM1 11/4885 |
| US-20060258741-A1 | C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders | PNMT, HTR2C, HTR2A | SLC6A4 52/4885SLC6A2 42/4885OPRM1 65/4885 |
| US-20050119349-A1 | Process for chlorinating tertiary alcohols | ADH1C, ADH5, ADH1A | SLC6A4 2388/4885SLC6A2 3649/4885OPRM1 446/4885 |
| US-20110251287-A1 | HCI POLYMORPHS OF 3-((2-(DIMETHYLAMINO)METHYL (CYCLOHEX-1-YL))PHENOL | HCN3, FANCI, HCN1 | SLC6A4 183/4885SLC6A2 269/4885OPRM1 17/4885 |
| US-20130245125-A1 | HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol | HCLS1, PEAK1, PAH | SLC6A4 878/4885SLC6A2 659/4885OPRM1 16/4885 |
| US-20070032552-A1 | Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof | REN, PKD1, ACMSD | SLC6A4 1254/4885SLC6A2 782/4885OPRM1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.