Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.32 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.32 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652962 | 1.00 | LMNA (0.38) | LMNAGAANPC1RAB9APDE2A | |
| SCHEMBL6379396 | 0.82 | KDM4E (0.33) | GAA | |
| SCHEMBL6379398 | 0.82 | KDM4E (0.33) | GAA | |
| SCHEMBL5775466 | 0.81 | IDH1 (0.32) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1201585 | 0.81 | IDH1 (0.32) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1201584 | 0.80 | — | — | |
| SCHEMBL6382954 | 0.79 | ABL1 (0.35) | — | |
| SCHEMBL414425 | 0.76 | — | — | |
| SCHEMBL1133427 | 0.74 | LMNA (0.43) | LMNAGAANPC1RAB9APDE2A | |
| SCHEMBL420758 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1352901-B1 | Process for the preparation of cyclic diketones | SYNGENTA PARTICIPATIONS AG (CH) | 2008-10-01 | — | — | EP | disclosed |
| US-7135574-B2 | Converting substituted mono or bicyclic lactones in presence of an amine base and a catalytic amount of a cyanide or alkali or alkaline metal alcoholate, to a salt, reacting the salt with carbonyl compound containing an organic substituent | SYNGENTA CROP PROTECTION, INC. (US) | 2006-11-14 | — | — | US | disclosed |
| US-20050159314-A1 | Process for the preparation of cyclic diketones | SCHNEIDER HERMANN (CH) | 2005-07-21 | — | — | US | disclosed |
| EP-1114030-B1 | PYRIDINE KETONES USEFUL AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-01 | — | — | EP | disclosed |
| EP-1250047-B9 | HERBICIDAL COMPOSITION | SYNGENTA PARTICIPATIONS AG (CH) | 2005-05-18 | — | — | EP | disclosed |
| US-6890885-B2 | Herbicidal composition | SYNGENTA CORP PROTECTION, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1520472-A2 | Herbicidal compositions comprising pyridoyl-1,3-cyclodiones | Syngenta Participations AG (CH) | 2005-04-06 | — | — | EP | disclosed |
| EP-1250047-B1 | HERBICIDAL COMPOSITION | SYNGENTA PARTICIPATIONS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6855831-B2 | Process for the preparation of cyclic diketones | SYNGENTA CROP PROTECTION, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040106519-A1 | Herbicidal composition | SYNGENTA CROP PROTECTION, INC. | 2004-06-03 | — | — | US | disclosed |
| US-20030199708-A1 | Process for the preparation of cyclic diketones | SYNGENTA CROP PROTECTION, INC. | 2003-10-23 | — | — | US | disclosed |
| EP-1352901-A2 | Process for the preparation of cyclic diketones | Syngenta Participations AG (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6498125-B2 | Pyridine ketones useful as herbicides | SYNGENTA PARTICIPATIONS AG (CH) | 2002-12-24 | — | — | US | disclosed |
| EP-1250047-A2 | HERBICIDAL COMPOSITION | Syngenta Participations AG (CH) | 2002-10-23 | — | — | EP | disclosed |
| US-20020016345-A1 | Pyridine ketones useful as herbicides | SYNGENTA PARTICIPATIONS AG (CH) | 2002-02-07 | — | — | US | disclosed |
| WO-2001054501-A2 | HERBICIDAL COMPOSITION | SYNGENTA PARTICIPATIONS AG (CH) | 2001-08-02 | — | — | WO | disclosed |
| EP-1114030-A1 | PYRIDINE KETONES USEFUL AS HERBICIDES | Syngenta Participations AG (CH) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000015615-A1 | PYRIDINE KETONES USEFUL AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106519-A1 | Herbicidal composition | DDT, ACHE, CYP1B1 | LMNA 4519/4885GAA 561/4885NPC1 4467/4885 |
| US-20030199708-A1 | Process for the preparation of cyclic diketones | XDH, NDUFS6, SQOR | LMNA 1282/4885GAA 402/4885NPC1 2439/4885 |
| US-20020016345-A1 | Pyridine ketones useful as herbicides | DDT, PDHA1, IDH2 | LMNA 4284/4885GAA 721/4885NPC1 4388/4885 |
| US-20050159314-A1 | Process for the preparation of cyclic diketones | NDUFS6, NDUFS4, NDUFV1 | LMNA 815/4885GAA 508/4885NPC1 2575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.