Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.33 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.33 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.33 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.33 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.33 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.33 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.33 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667252 | 0.89 | OPRM1 (0.37) | MAOAOPRL1ATP1A1ATP1B1ATP1A3 | |
| SCHEMBL4665510 | 0.87 | SIGMAR1 (0.36) | MAOAOPRL1ATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6936768 | 0.81 | SLC6A9 (0.39) | MAOAOPRL1TRPA1LMNAOPRM1 | |
| Hydrochloric Acid SCHEMBL7741185 | 0.80 | OPRL1 (0.39) | MAOAOPRL1TRPA1LMNAOPRM1 | |
| SCHEMBL4664194 | 0.80 | TACR1 (0.34) | MAOAATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL4664155 | 0.75 | OPRK1 (0.38) | OPRL1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL4663552 | 0.75 | CHRM2 (0.38) | MAOAOPRL1ATP1A1ATP1B1ATP1A3 | |
| SCHEMBL5719790 | 0.75 | ATP1A1 (0.33) | MAOAATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL4665556 | 0.75 | SIGMAR1 (0.39) | OPRL1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL4667320 | 0.73 | OPRK1 (0.50) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |