Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692974 | 0.90 | PPARG (0.32) | PTGDR2PPARGFFAR1TLR8 | |
| SCHEMBL4787114 | 0.75 | TLR8 (0.38) | TLR8 | |
| SCHEMBL4694546 | 0.66 | CRHR1 (0.39) | TLR8 | |
| SCHEMBL4694406 | 0.65 | CRHR1 (0.33) | — | |
| SCHEMBL4690582 | 0.65 | CRHR1 (0.53) | — | |
| SCHEMBL4693232 | 0.65 | ATP4A (0.35) | TLR8KDM4E | |
| SCHEMBL3935197 | 0.65 | SMPD3 (0.35) | — | |
| SCHEMBL4694389 | 0.65 | CYP2A6 (0.36) | TLR8 | |
| SCHEMBL4694319 | 0.64 | CRHR1 (0.37) | TLR8 | |
| SCHEMBL4695451 | 0.64 | TLR8 (0.32) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |