Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690131 | 0.90 | PTGDR2 (0.32) | PPARGFFAR1TLR8PTGDR2 | |
| SCHEMBL4787114 | 0.75 | TLR8 (0.38) | CRHR1TLR8 | |
| SCHEMBL4693619 | 0.67 | CRHR1 (0.67) | CRHR1PTGDR2 | |
| SCHEMBL4693477 | 0.67 | CRHR1 (0.67) | CRHR1PTGDR2 | |
| SCHEMBL4690722 | 0.66 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL4694546 | 0.66 | CRHR1 (0.39) | CRHR1TLR8 | |
| SCHEMBL4690582 | 0.65 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL4693232 | 0.65 | ATP4A (0.35) | TLR8 | |
| SCHEMBL3935197 | 0.65 | SMPD3 (0.35) | CRHR1 | |
| SCHEMBL4694389 | 0.65 | CYP2A6 (0.36) | CRHR1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |