Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282844 | 0.88 | GRIN2B (0.44) | S1PR5S1PR1DRD2KCNH2 | |
| SCHEMBL4694985 | 0.88 | GRIN2B (0.44) | S1PR5S1PR1DRD2KCNH2 | |
| SCHEMBL4689903 | 0.80 | P2RX7 (0.41) | MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4691802 | 0.78 | CCR5 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3284078 | 0.77 | CHRNA4 (0.39) | KDM4E | |
| SCHEMBL4692840 | 0.76 | PARP1 (0.40) | KMT2ADRD2KDM4EALDH1A1 | |
| SCHEMBL4694455 | 0.75 | CHRNB2 (0.44) | MEN1KMT2AKCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4693059 | 0.75 | CCR5 (0.37) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4694264 | 0.75 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL3284141 | 0.75 | CCR5 (0.42) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |