Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.35 |
| ▸ | CTSS | P25774 | 10/20 | 0.35 |
| ▸ | CTSB | P07858 | 9/20 | 0.35 |
| ▸ | CTSK | P43235 | 8/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235527 | 0.87 | CTSL (0.44) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4700769 | 0.84 | CTSL (0.38) | CTSLCTSSCTSBCTSKUSP28 | |
| SCHEMBL4698852 | 0.77 | CTSK (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702624 | 0.77 | RORC (0.40) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699954 | 0.77 | CTSL (0.37) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4700965 | 0.76 | BRD4 (0.36) | CTSB | |
| SCHEMBL4704763 | 0.76 | CTSS (0.43) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703889 | 0.76 | CTSS (0.37) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701283 | 0.75 | CTSL (0.54) | CTSLCTSSCTSBCTSKPRKD1 | |
| SCHEMBL4704047 | 0.75 | CTSL (0.54) | CTSLCTSSCTSBCTSKPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |