Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.44 |
| ▸ | CTSS | P25774 | 11/20 | 0.44 |
| ▸ | CTSB | P07858 | 10/20 | 0.44 |
| ▸ | CTSK | P43235 | 11/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702624 | 0.89 | RORC (0.40) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4704763 | 0.88 | CTSS (0.43) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703889 | 0.88 | CTSS (0.37) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701287 | 0.87 | CTSL (0.35) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4703250 | 0.83 | CTSL (0.46) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4703327 | 0.83 | CTSL (0.46) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4698852 | 0.83 | CTSK (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703732 | 0.82 | ME2 (0.43) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4700965 | 0.82 | BRD4 (0.36) | CTSB | |
| SCHEMBL4699954 | 0.81 | CTSL (0.37) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |