Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.39 |
| ▸ | CTSS | P25774 | 8/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.37 |
| ▸ | CTSB | P07858 | 5/20 | 0.37 |
| ▸ | CTSL | P07711 | 7/20 | 0.35 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700965 | 0.89 | BRD4 (0.36) | CTSB | |
| SCHEMBL4699954 | 0.87 | CTSL (0.37) | CTSKCTSSCTSBCTSL | |
| SCHEMBL6235527 | 0.83 | CTSL (0.44) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4702624 | 0.82 | RORC (0.40) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4704763 | 0.81 | CTSS (0.43) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4703732 | 0.81 | ME2 (0.43) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4703889 | 0.81 | CTSS (0.37) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4704247 | 0.80 | DPP4 (0.33) | — | |
| SCHEMBL4701287 | 0.77 | CTSL (0.35) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4699525 | 0.72 | CTSL (0.38) | CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |