Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL822698 | 0.83 | HSD11B1 (0.68) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| SCHEMBL889637 | 0.77 | HSD11B1 (0.56) | HSD11B1DRD2KMT2ATSHRAVPR1A | |
| SCHEMBL392717 | 0.73 | HSD11B1 (0.53) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| SCHEMBL13872765 | 0.73 | KMT2A (0.54) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| SCHEMBL7454054 | 0.73 | HSD11B1 (0.53) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| Potassium Ion SCHEMBL4705991 | 0.73 | HSD11B1 (0.45) | HSD11B1DRD2KMT2ATSHRMEN1 | |
| SCHEMBL14425750 | 0.71 | HSD11B1 (0.50) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| SCHEMBL974759 | 0.71 | ALDH1A1 (0.69) | DRD2KMT2ATSHRMEN1L3MBTL1 | |
| SCHEMBL19798383 | 0.71 | HSD11B1 (0.50) | HSD11B1DRD2KMT2ATSHRL3MBTL1 | |
| SCHEMBL12911795 | 0.71 | HSD11B1 (0.50) | HSD11B1DRD2KMT2ATSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465744-B2 | Triazole compounds and the therapeutic use thereof | ABBOTT GMBH & CO. KG (DE) | 2008-12-16 | — | — | US | disclosed |
| EP-1594861-B1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-06-18 | — | — | EP | disclosed |
| US-20060241137-A1 | Dopamine-D3-receptor antagonists/agonists; high selectivity, bioavailability and high cerebral availability; central nervous system diorders; 2-{3-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]propyl}-7-propionyl-1,2,3,4-tetrahydroisoquinoline | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2006-10-26 | — | — | US | disclosed |
| EP-1594861-A1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | Abbott GmbH & Co. KG (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069830-A1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241137-A1 | Dopamine-D3-receptor antagonists/agonists; high selectivity, bioavailability and high cerebral availability; central nervous system diorders; 2-{3-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]propyl}-7-propionyl-1,2,3,4-tetrahydroisoquinoline | DRD3, SLC6A3, ADORA3 | HSD11B1 1302/4885DRD2 4/4885KMT2A 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.