Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725656 | 0.88 | KMT2A (0.45) | MAPTPOLBDRD3LMNAALDH1A1 | |
| SCHEMBL4727679 | 0.85 | ALDH1A1 (0.48) | MAPTGAATSHRDRD3LMNA | |
| SCHEMBL4725768 | 0.85 | MAPT (0.51) | MAPTGAATSHRDRD3LMNA | |
| SCHEMBL4729823 | 0.83 | DRD3 (0.49) | MAPTGAADRD3LMNAALDH1A1 | |
| SCHEMBL4727604 | 0.83 | MEN1 (0.47) | MAPTTSHRDRD3LMNAALDH1A1 | |
| SCHEMBL4726498 | 0.82 | ALDH1A1 (0.44) | MAPTPOLBDRD3LMNAALDH1A1 | |
| SCHEMBL4727053 | 0.82 | LMNA (0.52) | MAPTGAATSHRLMNANPSR1 | |
| SCHEMBL4726285 | 0.82 | PKM (0.48) | MAPTDRD3LMNATP53CNR2 | |
| SCHEMBL4729520 | 0.82 | MOGAT2 (0.44) | DRD3LMNACNR2SMN1; SMN2MGAT2 | |
| SCHEMBL4725665 | 0.82 | GHSR (0.44) | MAPTDRD3LMNACNR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |