Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725295 | 0.93 | SMN1; SMN2 (0.55) | SMN1; SMN2TRIM24ALPLTP53ALDH1A1 | |
| SCHEMBL4728553 | 0.91 | ALPL (0.44) | SMN1; SMN2ALPLTP53ALDH1A1HTT | |
| SCHEMBL4727053 | 0.85 | LMNA (0.52) | SMN1; SMN2ALPLALDH1A1HTTNPSR1 | |
| SCHEMBL4779869 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2TRIM24ALPLALDH1A1KMT2A | |
| SCHEMBL4726021 | 0.84 | LMNA (0.54) | TRIM24ALPLTP53HTTNPSR1 | |
| SCHEMBL4726323 | 0.82 | MAPT (0.42) | SMN1; SMN2ALPLALDH1A1HTTCNR2 | |
| SCHEMBL4725656 | 0.81 | KMT2A (0.45) | SMN1; SMN2ALDH1A1HTTCNR2DRD3 | |
| SCHEMBL4727679 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2TP53ALDH1A1CNR2DRD3 | |
| SCHEMBL4726489 | 0.80 | LMNA (0.47) | TP53ALDH1A1HTTNPSR1KMT2A | |
| SCHEMBL4728002 | 0.80 | MOGAT2 (0.45) | TP53CNR2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |