Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KAT7 | O95251 | 1/20 | 0.36 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728553 | 0.92 | ALPL (0.44) | LMNADRD3ALDH1A1HTTALPL | |
| SCHEMBL4727679 | 0.88 | ALDH1A1 (0.48) | MAPTLMNADRD3ALDH1A1UBE2N | |
| SCHEMBL4725656 | 0.88 | KMT2A (0.45) | MAPTLMNADRD3ALDH1A1HTT | |
| SCHEMBL4727053 | 0.86 | LMNA (0.52) | MAPTLMNANPSR1ALDH1A1HTT | |
| SCHEMBL4729316 | 0.82 | CYP19A1 (0.48) | LMNADRD3NPSR1ALDH1A1HTT | |
| SCHEMBL4725768 | 0.81 | MAPT (0.51) | MAPTLMNADRD3ALDH1A1HTT | |
| SCHEMBL4725665 | 0.80 | GHSR (0.44) | MAPTLMNADRD3CNR2KMT2A | |
| SCHEMBL4726285 | 0.80 | PKM (0.48) | MAPTLMNADRD3HTTCNR2 | |
| SCHEMBL4729520 | 0.80 | MOGAT2 (0.44) | LMNADRD3UBE2NHTTCNR2 | |
| SCHEMBL4729823 | 0.80 | DRD3 (0.49) | MAPTLMNADRD3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |