SCHEMBL472995

SCHEMBL472995

COC(=O)c1cnc(Br)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 1/20 0.42
KDR P35968 1/20 0.42
CSNK2B P67870 1/20 0.42
CSNK2A1 P68400 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
NPSR1 Q6W5P4 3/20 0.42
NCOA1 Q15788 2/20 0.42
NCOA3 Q9Y6Q9 2/20 0.42
FFAR2 O15552 1/20 0.42
LMNA P02545 1/20 0.42
PPARG P37231 1/20 0.42
NCOA2 Q15596 1/20 0.42
MAPK1 P28482 4/20 0.39
ALDH1A1 P00352 4/20 0.39
CRBN Q96SW2 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
HPGD P15428 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23422044 0.86 FFAR2 (0.38) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL21836283 0.82 ALDH1A1 (0.42) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL4292895 0.80 HCAR2 (0.42) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL1107386 0.80 HCAR2 (0.68) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL274346 0.79 CDC7 (0.59) LMNAMAPK1ALDH1A1SMN1; SMN2HPGD
SCHEMBL21912862 0.79 ALDH1A1 (0.55) HCAR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL324369 0.79
SCHEMBL2583653 0.78 ALDH1A1 (0.49) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL23146191 0.78 HCAR2 (0.41) CSNK2A2KDRCSNK2BCSNK2A1HCAR2
SCHEMBL33099 0.78 KDM4E (0.43) CSNK2A2KDRCSNK2BCSNK2A1HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 540 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4041730-B1 SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2026-05-13 EP disclosed
EP-4727546-A2 PROTEOSOME COMPLEX INHIBITORS TARGETING CLPP1P2 PROTEASE The Global Alliance for TB Drug Development, Inc. (US) 2026-04-22 EP disclosed
US-12600716-B2 Compounds for modulating activity of FXR and uses thereof GANNEX PHARMA CO. LTD. (CN) 2026-04-14 US disclosed
US-12590062-B2 PD-1/PD-L1 inhibitors GILEAD SCIENCES, INC. (US) 2026-03-31 US disclosed
US-12583851-B2 Heteroaryl-substituted pyrazine derivatives as pesticides ELANCO ANIMAL HEALTH GMBH (DE) 2026-03-24 US disclosed
EP-4073070-B1 COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF GANNEX PHARMA CO LTD (CN) 2026-02-18 EP disclosed
US-20260035361-A1 COMPOUNDS FOR MODULATING HUR (ELAVL1) SHANGHAI DEGRON BIOMEDICAL TECH CO LTD (CN) 2026-02-05 US disclosed
US-12540134-B2 Inhibitors of adrenoreceptor ADRAC2 BAYER AKTIENGESELLSCHAFT (DE) 2026-02-03 US disclosed
EP-4676923-A1 BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS Cancer Research Technology Limited (GB) 2026-01-14 EP disclosed
EP-4667054-A2 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY Novartis AG (CH) 2025-12-24 EP disclosed
WO-2006015124-A2 FUSED RING HETEROCYCLE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2006-02-09 WO disclosed
US-20050250784-A1 Inhibitors of histone deacetylase MIIKANA THERAPEUTICS CORPORATION 2005-11-10 US disclosed
US-20050234033-A1 Inhibitors of histone deacetylase MIIKANA THERAPEUTICS 2005-10-20 US disclosed
WO-2005086898-A2 INHIBITORS OF HISTONE DEACETYLASE MIIKANA THERAPEUTICS, INC. (US) 2005-09-22 WO disclosed
US-20050197336-A1 Inhibitors of histone deacetylase MIIKANA THERAPEUTICS CORPORATION 2005-09-08 US disclosed
WO-2005075469-A1 THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-08-18 WO disclosed
WO-2005075469-A1 THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-08-18 WO disclosed
WO-2005026149-A1 PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY ASTRAZENECA AB (SE) 2005-03-24 WO disclosed
US-4089865-A Certain thiazole compounds SYNTEX (U.S.A.) INC. (US) 1978-05-16 US disclosed
US-4001421-A THIAZOLE CARDIOVASCULAR AGENTS SYNTEX (U.S.A.) INC. (US) 1977-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583851-B2 Heteroaryl-substituted pyrazine derivatives as pesticides CBR3, CYCS, CWC15 CSNK2A2 751/4885KDR 4066/4885CSNK2B 739/4885
US-12600716-B2 Compounds for modulating activity of FXR and uses thereof FXR1, NR1H4, FXR2 CSNK2A2 1687/4885KDR 2866/4885CSNK2B 1598/4885
US-20050197336-A1 Inhibitors of histone deacetylase HDAC1, HDAC11, HDAC10 CSNK2A2 193/4885KDR 4733/4885CSNK2B 167/4885
US-12540134-B2 Inhibitors of adrenoreceptor ADRAC2 ADRA2C, ADRB3, ADRB2 CSNK2A2 715/4885KDR 1193/4885CSNK2B 735/4885
US-12590062-B2 PD-1/PD-L1 inhibitors CD274, PDCD1LG2, PDCD1 CSNK2A2 2186/4885KDR 819/4885CSNK2B 1827/4885
US-20260035361-A1 COMPOUNDS FOR MODULATING HUR (ELAVL1) ELAVL1, ELAVL3, HNRNPL CSNK2A2 1728/4885KDR 2640/4885CSNK2B 1774/4885
US-20050250784-A1 Inhibitors of histone deacetylase HDAC1, HDAC11, HDAC10 CSNK2A2 193/4885KDR 4733/4885CSNK2B 167/4885
US-20050234033-A1 Inhibitors of histone deacetylase HDAC1, HDAC11, HDAC10 CSNK2A2 193/4885KDR 4733/4885CSNK2B 167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.