Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ME2 | P23368 | 1/20 | 0.36 |
| ▸ | ME1 | P48163 | 1/20 | 0.36 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4803555 | 0.89 | ME2 (0.39) | ALDH1A1ME2ME1ME3KDM4E | |
| SCHEMBL4738708 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRACHEHTR1A | |
| SCHEMBL4734210 | 0.84 | HTR1A (0.47) | ALDH1A1ME2ME1ME3KDM4E | |
| SCHEMBL4735318 | 0.80 | OPRM1 (0.37) | MEN1KMT2AATMALDH1A1ME2 | |
| SCHEMBL4740309 | 0.80 | LMNA (0.46) | MEN1KMT2AATMALDH1A1KDM4E | |
| SCHEMBL4736577 | 0.79 | TSHR (0.49) | MEN1KMT2AATMALDH1A1KDM4E | |
| SCHEMBL4735549 | 0.79 | MEN1 (0.43) | MEN1KMT2AATMALDH1A1KDM4E | |
| SCHEMBL4739217 | 0.78 | MEN1 (0.42) | MEN1KMT2AATMALDH1A1ME2 | |
| SCHEMBL4735156 | 0.76 | KCNH2 (0.39) | ALDH1A1KDM4ETSHRMAPTCYP3A4 | |
| SCHEMBL3830332 | 0.76 | MEN1 (0.45) | MEN1KMT2AALDH1A1ME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |