Sugi Predict

Sugi Predict / Compounds / SCHEMBL4753377

SCHEMBL4753377

SCHEMBL4753377

CC(C)(C)OC(=O)c1ccc(NN)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NNMT P40261 2/20 0.45
▸ CA12 O43570 1/20 0.43
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA9 Q16790 1/20 0.43
▸ CA14 Q9ULX7 1/20 0.43
▸ HCAR3 P49019 6/20 0.42
▸ MAPK1 P28482 2/20 0.42
▸ CRBN Q96SW2 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ ALOX15 P16050 1/20 0.40
▸ TET2 Q6N021 1/20 0.39
▸ OGFOD1 Q8N543 1/20 0.39
▸ TET1 Q8NFU7 1/20 0.39
▸ EGLN2 Q96KS0 1/20 0.39
▸ EGLN1 Q9GZT9 1/20 0.39
▸ HIF1AN Q9NWT6 1/20 0.39
▸ DEGS1 O15121 1/20 0.38
▸ GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30096924 1.00 NNMT (0.45) NNMTCA12CA1CA2CA9
SCHEMBL13739418 0.83 MAPK1 (0.61) NNMTCA12CA1CA2CA9
SCHEMBL4751860 0.82 NAMPT (0.41) NNMTHCAR3DEGS1
SCHEMBL5089206 0.81 HCAR3 (0.49) NNMTCA12CA1CA2CA9
SCHEMBL12163093 0.81 NNMT (0.38) NNMTHCAR3KDM4EDEGS1GAA
SCHEMBL15258755 0.81 GAA (0.44) NNMTHCAR3MAPK1KDM4EL3MBTL1
SCHEMBL23133523 0.80 HCAR3 (0.65) HCAR3CRBN
SCHEMBL623715 0.79 GABRA1 (0.55) NNMTCA12CA1CA2CA9
SCHEMBL30556509 0.79 DEGS1 (0.40) HCAR3CRBNTET2OGFOD1TET1
SCHEMBL25336302 0.79 DEGS1 (0.40) HCAR3CRBNTET2OGFOD1TET1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12384769-B2 Heteroaryl-substituted aminoalkyl azole compounds as pesticides ELANCO ANIMAL HEALTH GMBH (DE) 2025-08-12 — — US disclosed
CN-115605467-B PHD inhibitor compounds, compositions and uses thereof 阿克比治疗有限公司 2025-06-13 — — CN disclosed
CN-120004851-A PHD inhibitor compounds, compositions and uses thereof 阿克比治疗有限公司 2025-05-16 — — CN disclosed
CN-119823097-A PHD inhibitor compounds, compositions and uses 阿克比治疗有限公司 2025-04-15 — — CN disclosed
CN-115551845-B PHD inhibitor compounds, compositions and uses 阿克比治疗有限公司 2025-02-28 — — CN disclosed
CN-113939509-B Novel heteroaryl substituted aminoalkylazole compounds as pesticides 拜耳动物保健有限责任公司 2024-11-29 — — CN disclosed
CN-117800904-A ROR gamma inhibitors containing sulfonyl structures 正大天晴药业集团股份有限公司 2024-04-02 — — CN disclosed
CN-113166061-B ROR gamma inhibitors containing sulfonyl structures 正大天晴药业集团股份有限公司 2023-11-21 — — CN disclosed
US-20230227426-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE AKEBIA THERAPEUTICS, INC. (US) 2023-07-20 — — US disclosed
US-20230227426-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE AKEBIA THERAPEUTICS, INC. (US) 2023-07-20 — — US disclosed
US-20120121727-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-17 — — US disclosed
US-20120121727-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-17 — — US disclosed
US-20110301148-A1 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-12-08 — — US disclosed
US-20100305085-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-12-02 — — US disclosed
US-20100305085-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-12-02 — — US disclosed
US-20100093803-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERRING PHARMA AKTIENGELLSCHAFT (DE) 2010-04-15 — — US disclosed
US-20100093803-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERRING PHARMA AKTIENGELLSCHAFT (DE) 2010-04-15 — — US disclosed
CN-101600710-A Bipyridyl dihydropyrazolone that replaces and their application BAYER HEALTHCARE AG (DE) 2009-12-09 — — CN disclosed
WO-2008067871-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-06-12 — — WO disclosed
WO-2008067874-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-06-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384769-B2 Heteroaryl-substituted aminoalkyl azole compounds as pesticides DDT, CRY1, AAAS NNMT 3682/4885CA12 4609/4885CA1 3907/4885
US-20100093803-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF DCK, THPO, QDPR NNMT 1279/4885CA12 4822/4885CA1 4867/4885
US-20230227426-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE HIF1AN, EGLN3, PHF20 NNMT 2221/4885CA12 1726/4885CA1 1102/4885
US-20100305085-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES THPO, PFKP, HPGDS NNMT 2268/4885CA12 4702/4885CA1 4858/4885
US-20110301148-A1 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF NR3C2, NR3C1, NR5A2 NNMT 715/4885CA12 1429/4885CA1 1234/4885
US-20120121727-A1 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES THPO, PFKP, DCK NNMT 1810/4885CA12 4857/4885CA1 4885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.