Sugi Predict

Sugi Predict / Compounds / SCHEMBL475367

SCHEMBL475367

SCHEMBL475367

O=Cc1ccc(C(F)F)nc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.42
▸ KDM4E B2RXH2 3/20 0.39
▸ KCNJ1 P48048 1/20 0.39
▸ DRD1 P21728 4/20 0.36
▸ POLB P06746 2/20 0.36
▸ TYR P14679 1/20 0.34
▸ CYP2A6 P11509 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ ALDH5A1 P51649 1/20 0.33
▸ ABAT P80404 1/20 0.33
▸ LMNA P02545 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ ALDH3A1 P30838 1/20 0.32
▸ ALDH1A3 P47895 1/20 0.32
▸ CASP6 P55212 1/20 0.32
▸ DRD2 P14416 1/20 0.32
▸ DRD4 P21917 1/20 0.32
▸ DRD5 P21918 1/20 0.32
▸ DRD3 P35462 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29900333 1.00 ALDH1A1 (0.42) ALDH1A1L3MBTL1KDM4EKCNJ1DRD1
SCHEMBL18921493 0.81 ALDH1A1 (0.41) ALDH1A1KDM4ELMNA
SCHEMBL29966715 0.81 ALDH1A1 (0.41) ALDH1A1KDM4ELMNA
SCHEMBL18921491 0.81 ALDH1A1 (0.41) ALDH1A1KDM4ELMNA
SCHEMBL27741707 0.79 ESR1 (0.30) —
SCHEMBL1495485 0.79 ALDH1A1 (0.40) ALDH1A1
SCHEMBL10865551 0.79 FDPS (0.31) —
SCHEMBL2555492 0.79 TYR (0.48) ALDH1A1L3MBTL1KDM4EKCNJ1TYR
SCHEMBL30453932 0.79 TYR (0.48) ALDH1A1L3MBTL1KDM4EKCNJ1TYR
SCHEMBL27795132 0.77 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509439-B2 Anti-malarial agents UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2025-12-30 — — US disclosed
US-20240360157-A1 TYK2 INHIBITORS BIOGEN MA INC. 2024-10-31 — — US disclosed
US-20230174503-A1 NEW ANTI-MALARIAL AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2023-06-08 — — US disclosed
US-20230174503-A1 NEW ANTI-MALARIAL AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2023-06-08 — — US disclosed
US-20230174503-A1 NEW ANTI-MALARIAL AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2023-06-08 — — US disclosed
US-20230086702-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2023-03-23 — — US disclosed
CN-108137513-B Pyrimidine derivatives ASKA 制药株式会社 2022-03-01 — — CN disclosed
EP-3956330-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF The Johns Hopkins University (US) 2022-02-23 — — EP disclosed
US-11254681-B2 Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases NUEVOLUTION A/S (DK) 2022-02-22 — — US disclosed
EP-3723807-B1 COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES H LUNDBECK AS (DK) 2021-10-20 — — EP disclosed
US-6022967-A 1-NITRO-2-CARBOXYVINYL- OR 1-NITRO-2-(DIMETHYLAMINO)VINYL-SUBSTITUTED IMIDAZOLIDINES OR TETRAHYDROPYRIMIDINES NIHON BAYER AGROCHEM K.K. (JP) 2000-02-08 — — US disclosed
US-5750704-A INSECTICIDES NIHON BAYER AGROCHEM K.K. (JP) 1998-05-12 — — US disclosed
US-5580889-A Insecticidal nitromethyl or niteoimino-heteromethyl-heterocyclics NIHON BAYER AGROCHEM K.K. (JP) 1996-12-03 — — US disclosed
US-5461167-A 2-chloro-5-chloromethyl thiazole; insecticide NIHON BAYER AGROCHEM K.K. (JP) 1995-10-24 — — US disclosed
US-5428032-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1995-06-27 — — US disclosed
US-5298507-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1994-03-29 — — US disclosed
US-5204360-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1993-04-20 — — US disclosed
US-5001138-A Insecticides NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) 1991-03-19 — — US disclosed
US-4845106-A INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-07-04 — — US disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11254681-B2 Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases PPARD, PPARG, RORC ALDH1A1 1245/4885L3MBTL1 4725/4885KDM4E 3194/4885
US-12509439-B2 Anti-malarial agents RCC1, PFN1, NHERF1 ALDH1A1 1353/4885L3MBTL1 3793/4885KDM4E 3704/4885
US-20230174503-A1 NEW ANTI-MALARIAL AGENTS QDPR, DHODH, G6PD ALDH1A1 1163/4885L3MBTL1 3970/4885KDM4E 1107/4885
US-20240360157-A1 TYK2 INHIBITORS TYK2, JAK2, ABL1 ALDH1A1 4716/4885L3MBTL1 2688/4885KDM4E 686/4885
US-20230086702-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF SNCA, PSEN2, PRNP ALDH1A1 1721/4885L3MBTL1 2687/4885KDM4E 2237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.