Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | MYC | P01106 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758286 | 0.90 | TSHR (0.36) | HCAR2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL4757355 | 0.84 | PYGM (0.39) | ALDH1A1LMNANOTUMHTTGAA | |
| SCHEMBL4757333 | 0.81 | OPRM1 (0.36) | ALDH1A1NOTUMTSHRSMN1; SMN2GAA | |
| SCHEMBL4758575 | 0.81 | OPRM1 (0.39) | NOTUMTSHR | |
| SCHEMBL4758254 | 0.80 | HCAR3 (0.39) | HCAR2ALDH1A1LMNAMAPTNOTUM | |
| SCHEMBL4758577 | 0.80 | TSHR (0.36) | ALDH1A1LMNAMAPTTP53NOTUM | |
| SCHEMBL4758583 | 0.79 | PYGL (0.38) | ALDH1A1LMNAMAPTNOTUMTSHR | |
| SCHEMBL4757340 | 0.79 | NOTUM (0.34) | NOTUM | |
| SCHEMBL5533759 | 0.78 | KDM4E (0.39) | ALDH1A1LMNAMAPTHTTTSHR | |
| SCHEMBL5452071 | 0.76 | ABCC1 (0.43) | HCAR2ALDH1A1LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |