Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 6/20 | 0.38 |
| ▸ | PYGM | P11217 | 6/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758577 | 0.87 | TSHR (0.36) | PYGLPYGMNOTUMTSHRKMT2A | |
| SCHEMBL4757355 | 0.86 | PYGM (0.39) | PYGLPYGMNOTUMALDH1A1LMNA | |
| SCHEMBL4758254 | 0.81 | HCAR3 (0.39) | NOTUMTSHRTDP1ALDH1A1LMNA | |
| SCHEMBL4758299 | 0.81 | LMNA (0.42) | PYGLPYGMTSHRKMT2AMEN1 | |
| SCHEMBL4757333 | 0.80 | OPRM1 (0.36) | NOTUMTSHRAKR1B1KMT2AALDH1A1 | |
| SCHEMBL4758575 | 0.80 | OPRM1 (0.39) | NOTUMTSHR | |
| SCHEMBL4758286 | 0.79 | TSHR (0.36) | NOTUMTSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL4757320 | 0.79 | HCAR2 (0.39) | NOTUMTSHRALDH1A1LMNAKDM4E | |
| SCHEMBL4757340 | 0.77 | NOTUM (0.34) | NOTUML3MBTL1 | |
| SCHEMBL4756162 | 0.76 | TDP1 (0.40) | NOTUMTSHRKMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |