Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776747 | 0.97 | PKM (0.43) | PKMTP53CHEK1AURKAJAK2 | |
| SCHEMBL4796331 | 0.76 | ADRA2A (0.37) | TP53ADORA2AADORA2BADORA1 | |
| SCHEMBL4778477 | 0.73 | MEN1 (0.45) | TP53KMT2AMAPTMEN1NPSR1 | |
| SCHEMBL4779650 | 0.70 | MAPT (0.46) | PKMKMT2AMAPTMEN1POLB | |
| SCHEMBL4774593 | 0.67 | ALDH1A1 (0.44) | KMT2AMAPTMEN1NPSR1CYP1A2 | |
| SCHEMBL4774611 | 0.66 | LTB4R (0.47) | KMT2AMAPTMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4776218 | 0.65 | CYP19A1 (0.42) | PKMKMT2AMAPTMEN1POLB | |
| SCHEMBL411205 | 0.65 | AOC3 (0.53) | LMNAALDH1A1TDP1 | |
| SCHEMBL5559803 | 0.65 | ALDH1A1 (0.64) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4776675 | 0.64 | HTR7 (0.47) | KMT2AMAPTNPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |