Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 3/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169066 | 0.82 | AKR1C3 (0.72) | AKR1C3AKR1C2TSHRPTGS1PTGS2 | |
| SCHEMBL29495930 | 0.80 | AKR1C3 (0.51) | AKR1C3AKR1C2ALDH1A1PTGS1PTGS2 | |
| SCHEMBL1195462 | 0.80 | AKR1C3 (0.51) | AKR1C3AKR1C2ALDH1A1PTGS1PTGS2 | |
| SCHEMBL20560610 | 0.78 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1PTGS2TAS2R14 | |
| SCHEMBL27510 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TSHRHDAC6CES2CES1 | |
| SCHEMBL28967024 | 0.76 | AKR1C3 (0.47) | AKR1C3AKR1C2ALDH1A1PTGS1PTGS2 | |
| SCHEMBL1194372 | 0.76 | GSK3B (0.52) | AKR1C3AKR1C2PTGS1PTGS2TAS2R14 | |
| SCHEMBL30782680 | 0.76 | ALDH1A1 (0.58) | AKR1C3AKR1C2ALDH1A1PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL8084573 | 0.75 | ALDH1A1 (0.57) | ALDH1A1TSHRHDAC6CES2CES1 | |
| Bromide SCHEMBL31026552 | 0.75 | ALDH1A1 (0.57) | ALDH1A1TSHRHDAC6CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450280-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450280-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| EP-3250565-B1 | TETRAZOLONES AS CARBOXYLIC ACID BIOISOSTERES | RIGEL PHARMACEUTICALS INC (US) | 2019-07-03 | — | — | EP | disclosed |
| EP-3250565-B1 | TETRAZOLONES AS CARBOXYLIC ACID BIOISOSTERES | RIGEL PHARMACEUTICALS INC (US) | 2019-07-03 | — | — | EP | disclosed |
| US-9988395-B2 | Antiparasitic compositions and methods utilizing substituted 5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridine derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-06-05 | — | — | US | disclosed |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2018-01-04 | — | — | US | disclosed |
| US-20170349606-A1 | ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED 5,5,7,7-TETRAMETHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE DERIVATIVES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-12-07 | — | — | US | disclosed |
| EP-3250565-A1 | TETRAZOLONES AS CARBOXYLIC ACID BIOISOSTERES | Rigel Pharmaceuticals, Inc. (US) | 2017-12-06 | — | — | EP | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2016-07-28 | — | — | US | disclosed |
| US-9193713-B2 | Compounds as cannabinoid receptor ligands | ABBVIE INC. (US) | 2015-11-24 | — | — | US | disclosed |
| EP-2851366-A1 | Compounds as cannabinoid receptor ligands | Abbvie Inc. (US) | 2015-03-25 | — | — | EP | disclosed |
| US-8492371-B2 | Compounds as cannabinoid receptor ligands | ABBVIE INC. (US) | 2013-07-23 | — | — | US | disclosed |
| EP-2411382-A1 | COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249129-A1 | COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2010-09-30 | — | — | US | disclosed |
| WO-2010111572-A1 | COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2010-09-30 | — | — | WO | disclosed |
| EP-2219629-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20090105306-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | US | disclosed |
| WO-2009048936-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105306-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | CNR1, CNR2, GPR18 | AKR1C3 898/4885AKR1C2 1083/4885ALDH1A1 926/4885 |
| US-10450280-B2 | Tetrazolones as a carboxylic acid bioisosteres | GLS, CYP11B2, GLS2 | AKR1C3 389/4885AKR1C2 485/4885ALDH1A1 515/4885 |
| US-20170349606-A1 | ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED 5,5,7,7-TETRAMETHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE DERIVATIVES | COX5B, COX6C, CYCS | AKR1C3 675/4885AKR1C2 1857/4885ALDH1A1 2095/4885 |
| US-20100249129-A1 | COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | CNR1, CNR2, GPR18 | AKR1C3 1025/4885AKR1C2 1105/4885ALDH1A1 660/4885 |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | AKR1C3 389/4885AKR1C2 485/4885ALDH1A1 515/4885 |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | AKR1C3 389/4885AKR1C2 485/4885ALDH1A1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.