Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 9/20 | 0.40 |
| ▸ | CA1 | P00915 | 8/20 | 0.40 |
| ▸ | CA9 | Q16790 | 7/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamide SCHEMBL29026073 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4ETSHRCA2CA1 | |
| Methanesulfonamide SCHEMBL4804491 | 0.81 | CA1 (0.53) | ALDH1A1KDM4ETSHRCA2CA1 | |
| Methanesulfonamide SCHEMBL4804172 | 0.81 | CA1 (0.53) | ALDH1A1KDM4ETSHRCA2CA1 | |
| SCHEMBL4878731 | 0.79 | CA1 (0.48) | ALDH1A1KDM4ETSHRCA2CA1 | |
| Ethanesulfonic Acid Amide SCHEMBL28038 | 0.77 | — | — | |
| Toluene SCHEMBL303284 | 0.76 | ACHE (0.55) | TSHRCA2CA1CA9CA12 | |
| SCHEMBL2005577 | 0.74 | CA2 (0.56) | ALDH1A1KDM4ETSHRCA2CA1 | |
| Ethylamine SCHEMBL29162867 | 0.74 | ALDH1A1 (0.56) | ALDH1A1TSHRTPMTPRSS1PRSS2 | |
| Ethanesulfonic Acid Amide SCHEMBL27415310 | 0.74 | CA2 (0.46) | CA2CA1CA9CA12CA6 | |
| Ethanesulfonic Acid Amide SCHEMBL3402460 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414154-B2 | Polyamine compounds and compositions for use in conjunction with cancer therapy | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-08-19 | — | — | US | disclosed |
| US-7314959-B2 | Amino thiol compounds and compositions for use in conjunction with cancer therapy | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-01-01 | — | — | US | disclosed |
| US-20050101676-A1 | Amino thiol compounds and compositions for use in conjunction with cancer therapy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-12 | — | — | US | disclosed |
| WO-2005014524-A2 | AMINO THIOL COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-02-17 | — | — | WO | disclosed |
| US-20050027016-A1 | Polyamine compounds and compositions for use in conjection with cancer therapy | FAHL KATHLEEN L (US) | 2005-02-03 | — | — | US | disclosed |
| EP-1478618-A1 | POLYAMINE COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20040225021-A1 | Polyamine compounds and compositions for use in conjunction with cancer therapy | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-11-11 | — | — | US | disclosed |
| US-20030185778-A1 | Polyamine compounds and compositions for use in conjunction with cancer therapy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-10-02 | — | — | US | disclosed |
| WO-2003066572-A1 | POLYAMINE COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040225021-A1 | Polyamine compounds and compositions for use in conjunction with cancer therapy | SRM, SMS, HNMT | ALDH1A1 926/4885KDM4E 1966/4885TSHR 4317/4885 |
| US-20050101676-A1 | Amino thiol compounds and compositions for use in conjunction with cancer therapy | SRM, MGMT, AADAT | ALDH1A1 692/4885KDM4E 2612/4885TSHR 3537/4885 |
| US-20050027016-A1 | Polyamine compounds and compositions for use in conjection with cancer therapy | SRM, SMS, SMOX | ALDH1A1 1265/4885KDM4E 2972/4885TSHR 4150/4885 |
| US-20030185778-A1 | Polyamine compounds and compositions for use in conjunction with cancer therapy | SRM, SMS, HNMT | ALDH1A1 926/4885KDM4E 1966/4885TSHR 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.