Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 12/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323719 | 0.77 | HTR7 (0.56) | HTR7FBP1PDK1FDPSSMN1; SMN2 | |
| SCHEMBL15331155 | 0.77 | HTR7 (0.56) | HTR7FBP1PDK1FDPSSMN1; SMN2 | |
| SCHEMBL1381549 | 0.76 | HTR7 (0.54) | HTR7FBP1PDK1FDPSSMN1; SMN2 | |
| SCHEMBL8412672 | 0.74 | HTR7 (0.56) | HTR7FBP1PDK1FDPSSMN1; SMN2 | |
| SCHEMBL10363092 | 0.74 | HTR7 (0.51) | HTR7FBP1PDK1FDPSSMN1; SMN2 | |
| SCHEMBL7020311 | 0.73 | FBP1 (0.42) | FBP1SMN1; SMN2HSD17B3 | |
| SCHEMBL9232146 | 0.73 | PDPK1 (0.36) | HTR7FBP1 | |
| SCHEMBL7020542 | 0.73 | APEX1 (0.46) | SMN1; SMN2 | |
| SCHEMBL7015079 | 0.73 | — | — | |
| SCHEMBL719258 | 0.72 | RAB9A (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439408-B2 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | BAYER CROPSCIENCE AG (DE) | 2008-10-21 | — | — | US | disclosed |
| US-7385093-B2 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2008-06-10 | — | — | US | disclosed |
| US-20060183914-A1 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | STRAUB ALEXANDER | 2006-08-17 | — | — | US | disclosed |
| US-20060183915-A1 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2006-08-17 | — | — | US | disclosed |
| US-7078527-B2 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | BAYER CROPSCIENCE AG (DE) | 2006-07-18 | — | — | US | disclosed |
| EP-1467980-B1 | METHOD FOR PRODUCING HALOGENATED 2-(3-BUTENYLSULFANYL)-1,3-THIAZOLES | BAYER CROPSCIENCE AG (DE) | 2005-07-27 | — | — | EP | disclosed |
| US-20050124816-A1 | reacting a 1-halo, mesylate, or tosylate-4,4-difluorobutene with a thiocyanate, giving a butenylthiocyanate; converting to a dithiocarbamate by reacting with hydrogen sulfide; condensation and cyclization with (chloro)acetaldehyde; circumvents 2-mercapto-1,3-thiazole intermediate; by-product inhibition | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2005-06-09 | — | — | US | disclosed |
| EP-1467980-A1 | METHOD FOR PRODUCING HALOGENATED 2-(3-BUTENYLSULFANYL)-1,3-THIAZOLES | Bayer CropScience AG (DE) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059896-A1 | METHOD FOR PRODUCING HALOGENATED 2-(3-BUTENYLSULFANYL)-1,3-THIAZOLES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-07-24 | — | — | WO | disclosed |
| EP-0749433-B1 | (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY | SYNGENTA LTD (GB) | 2003-05-07 | — | — | EP | disclosed |
| US-6156904-A | 2-(4-CHLORO-4,4-DIFLUOROBUTYLTHIO)THIAZOLE USED AS AGRICULTURAL NEMATOCIDE | ZENECA LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |
| US-6025497-A | Processes for the production of 5-chloro-2-(4,4-difluorobut-3-enylsulphonyl)thiazole | ZENECA LIMITED (GB) | 2000-02-15 | — | — | US | disclosed |
| EP-0977744-A1 | PROCESS FOR THE PRODUCTION OF 5-CHLORO-2- (4,4-DIFLUOROBUT-3-ENYLSULPHONYL) THIAZOLE AND INTERMEDIATES THEREFOR | ZENECA LIMITED (GB) | 2000-02-09 | — | — | EP | disclosed |
| US-5952359-A | NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES | ZENECA LIMITED (GB) | 1999-09-14 | — | — | US | disclosed |
| US-5912243-A | NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS | ZENECA LIMITED (GB) | 1999-06-15 | — | — | US | disclosed |
| WO-1998047884-A1 | PROCESS FOR THE PRODUCTION OF 5-CHLORO-2- (4,4-DIFLUOROBUT-3-ENYLSULPHONYL) THIAZOLE AND INTERMEDIATES THEREFOR | ZENECA LIMITED (GB) | 1998-10-29 | — | — | WO | disclosed |
| US-5705516-A | NEMATOCIDES, INSECTICIDES, ACARICIDES | ZENECA LIMITED (GB) | 1998-01-06 | — | — | US | disclosed |
| CN-1143958-A | (4,4-difluorobut-3-enylthio-)-substituted heterocyclic or carbocyclic ring compounds | ZENECA LTD (GB) | 1997-02-26 | — | — | CN | disclosed |
| EP-0749433-A1 | (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024403-A1 | (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY | ZENECA LIMITED (GB) | 1995-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124816-A1 | reacting a 1-halo, mesylate, or tosylate-4,4-difluorobutene with a thiocyanate, giving a butenylthiocyanate; converting to a dithiocarbamate by reacting with hydrogen sulfide; condensation and cyclization with (chloro)acetaldehyde; circumvents 2-mercapto-1,3-thiazole intermediate; by-product inhibition | TST, CBS, CTH | HTR7 2501/4885FBP1 153/4885PDK1 2134/4885 |
| US-20060183915-A1 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | TST, SULT1A1, CTH | HTR7 1501/4885FBP1 2149/4885PDK1 2831/4885 |
| US-20060183914-A1 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles | HCN4, HCN2, KCNH3 | HTR7 3034/4885FBP1 4141/4885PDK1 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.