Tetrahydropiperine

Tetrahydropiperine

SCHEMBL4898699

O=C(CCCCc1ccc2c(c1)OCO2)N1CCCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 2/20 1.00
HDAC1 Q13547 2/20 0.60
HDAC3 O15379 1/20 0.60
HDAC2 Q92769 1/20 0.60
HDAC6 Q9UBN7 1/20 0.60
MEN1 O00255 1/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.55
TSHR P16473 1/20 0.55
KMT2A Q03164 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
HDAC8 Q9BY41 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydropiperine SCHEMBL29392462 1.00 TRPV1 (1.00) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL14200777 0.99 TRPV1 (0.97) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL9425973 0.91 TRPV1 (0.83) TRPV1MEN1ALDH1A1LMNATSHR
SCHEMBL9425805 0.89 TRPV1 (0.81) TRPV1MEN1ALDH1A1LMNATSHR
SCHEMBL15985141 0.85 TRPV1 (0.74) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL4953724 0.83 TRPV1 (0.71) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL14200737 0.81 TRPV1 (0.69) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL9426173 0.81 TRPV1 (0.68) TRPV1MEN1ALDH1A1TSHRKMT2A
SCHEMBL24893059 0.80 TRPV1 (0.66) TRPV1HDAC1HDAC3HDAC2HDAC6
SCHEMBL3815431 0.80 TRPV1 (0.67) TRPV1MEN1ALDH1A1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120131527-A An anti-wrinkle skin care composition containing Ganoderma and yeast components 西沐臻品(上海)生物科技发展有限公司 2025-06-13 CN disclosed
US-20240285629-A1 Combination Therapy for Use in Treating Retroviral Infections CIPLA LIMITED (IN) 2024-08-29 US disclosed
US-20240109855-A1 ANTI-QUORUM SENSING, ANTI-BIOFILM, AND INFLAMMATION ATTENUATING COMPOUNDS, COMPOSITIONS, AND METHODS OF USING SAME B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD. AT BEN-GURION UNIVERSITY (IL) 2024-04-04 US disclosed
EP-3525825-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING RIFAXIMIN CIPLA LTD (IN) 2024-03-20 EP disclosed
CN-116869897-A Red-dispelling repair essence and preparation process thereof 广东华智化工研究院 2023-10-13 CN disclosed
CN-110087688-B Pharmaceutical composition comprising rifaximin 希普拉有限公司 2023-05-05 CN disclosed
US-20230119206-A1 COMPOSITIONS COMPRISING IBRUTINIB AND AN ALKALOID HAVING ENHANCED BIOAVAILABILITY CIPLA LIMITED (IN) 2023-04-20 US disclosed
US-20230119206-A1 COMPOSITIONS COMPRISING IBRUTINIB AND AN ALKALOID HAVING ENHANCED BIOAVAILABILITY CIPLA LIMITED (IN) 2023-04-20 US disclosed
US-11612612-B2 Pharmaceutical compositions CIPLA LIMITED (IN) 2023-03-28 US disclosed
CN-115475194-A A Chinese medicinal composition foot bath bag for treating loempe and its preparation method 象记(上海)生物科技有限公司 2022-12-16 CN disclosed
EP-3413913-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTI-RETROVIRAL DRUG AND A PHARMACOKINETIC ENHANCER Cipla Limited (IN) 2018-12-19 EP disclosed
WO-2018193470-A1 COMBINATION THERAPY FOR USE IN TREATING RETROVIRAL INFECTIONS CIPLA LIMITED (IN) 2018-10-25 WO disclosed
US-20180221427-A1 TRANSDERMAL FORMULATIONS FOR DELIVERY OF CAPSAICINOIDS DELIVRA INC. (CA) 2018-08-09 US disclosed
US-20180221427-A1 TRANSDERMAL FORMULATIONS FOR DELIVERY OF CAPSAICINOIDS DELIVRA INC. (CA) 2018-08-09 US disclosed
WO-2017138022-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTI-RETROVIRAL DRUG AND A PHARMACOKINETIC ENHANCER CIPLA LIMITED (IN) 2017-08-17 WO disclosed
US-20170232020-A1 PHARMACEUTICAL COMPOSITIONS CIPLA LTD (IN) 2017-08-17 US disclosed
US-20170232020-A1 PHARMACEUTICAL COMPOSITIONS CIPLA LTD (IN) 2017-08-17 US disclosed
US-20170232020-A1 PHARMACEUTICAL COMPOSITIONS CIPLA LTD (IN) 2017-08-17 US disclosed
WO-2017020125-A1 TRANSDERMAL FORMULATIONS FOR DELIVERY OF CAPSAICINOIDS DELIVRA INC. (CA) 2017-02-09 WO disclosed
US-20080146987-A1 TREATMENT OF A SKIN CONDITION USING A PIPERINE-BASED COMPOSITION IN CONJUNCTION WITH IRRADIATION OREGON HEALTH & SCIENCE UNIVERSITY (US) 2008-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109855-A1 ANTI-QUORUM SENSING, ANTI-BIOFILM, AND INFLAMMATION ATTENUATING COMPOUNDS, COMPOSITIONS, AND METHODS OF USING SAME FPR1, FPR2, IL1B TRPV1 481/4885HDAC1 448/4885HDAC3 449/4885
US-11612612-B2 Pharmaceutical compositions HAVCR2, APOB, ABCB11 TRPV1 4661/4885HDAC1 4219/4885HDAC3 4166/4885
US-20230119206-A1 COMPOSITIONS COMPRISING IBRUTINIB AND AN ALKALOID HAVING ENHANCED BIOAVAILABILITY BCL6B, BCL9, BCL6 TRPV1 4840/4885HDAC1 560/4885HDAC3 925/4885
US-20170232020-A1 PHARMACEUTICAL COMPOSITIONS HAVCR2, APOB, ABCB11 TRPV1 4661/4885HDAC1 4219/4885HDAC3 4166/4885
US-20180221427-A1 TRANSDERMAL FORMULATIONS FOR DELIVERY OF CAPSAICINOIDS TRPV1, TRPV4, TRPV2 TRPV1 1/4885HDAC1 2032/4885HDAC3 1654/4885
US-20240285629-A1 Combination Therapy for Use in Treating Retroviral Infections PAICS, HAVCR2, THPO TRPV1 4819/4885HDAC1 3952/4885HDAC3 4338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.