SCHEMBL490481

SCHEMBL490481

O=CC1=COC(Cc2ccccc2)O1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTRB1 P17538 1/20 0.36
F2 P00734 2/20 0.36
PRSS1 P07477 2/20 0.36
FASN P49327 1/20 0.35
GRM2 Q14416 1/20 0.33
ADH1B P00325 1/20 0.32
ADH1C P00326 1/20 0.32
ADH1A P07327 1/20 0.32
ADH7 P40394 1/20 0.32
CALM1 P0DP23 1/20 0.32
DDB1 Q16531 1/20 0.32
CRBN Q96SW2 1/20 0.32
TLR9 Q9NR96 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7718147 0.83 CTRB1 (0.33) CTRB1FASNGRM2
SCHEMBL5220133 0.80 HCAR2 (0.43)
SCHEMBL6863242 0.77 ADH1B (0.38) CTRB1F2PRSS1FASNGRM2
SCHEMBL17512439 0.75 CALM1 (0.39) CTRB1F2PRSS1FASNGRM2
SCHEMBL7593855 0.74 MAPT (0.40)
SCHEMBL5858339 0.73 CTRB1 (0.38) CTRB1FASNGRM2TLR9
SCHEMBL3744743 0.73 CTRB1 (0.35) CTRB1F2PRSS1FASNGRM2
SCHEMBL5754991 0.73 TAAR1 (0.39) CTRB1FASNGRM2
SCHEMBL746094 0.73 CTRB1 (0.35) CTRB1FASNGRM2
SCHEMBL3972137 0.73 CTRB1 (0.35) CTRB1FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2662434-B2 Use of specific compounds for enhancing odours SYMRISE AG (DE) 2023-08-16 EP claimed
US-10920170-B2 Fragrance mixtures containing tricyclo[5.2.1.0]-decane-8-ethyl ether SYMRISE AG (DE) 2021-02-16 US claimed
US-20200063063-A1 FRAGRANCE MIXTURES CONTAINING TRICYCLO[5.2.1.0]-DECANE-8-ETHYL ETHER SYMRISE AG (DE) 2020-02-27 US claimed
EP-3601509-A1 FRAGRANCE MIXTURES CONTAINING TRICYCLO[5.2.1.0]-DECANE-8-ETHYL ETHER Symrise AG (DE) 2020-02-05 EP claimed
EP-2662098-B1 Use of specific compounds for changing odours SYMRISE AG (DE) 2018-10-24 EP claimed
WO-2018171872-A1 FRAGRANCE MIXTURES CONTAINING TRICYCLO[5.2.1.0]-DECANE-8-ETHYL ETHER SYMRISE AG (DE) 2018-09-27 WO claimed
EP-2662434-B1 Use of specific compounds for enhancing odours SYMRISE AG (DE) 2018-03-21 EP claimed
US-9340751-B2 Use of specific compounds for modifying odors SYMRISE AG (DE) 2016-05-17 US claimed
US-20130303432-A1 Use Of Specific Compounds For Modifying Odors SYMRISE AG (DE) 2013-11-14 US claimed
EP-2662434-A1 Use of specific compounds for enhancing odours Symrise AG (DE) 2013-11-13 EP claimed
US-7226921-B2 Compounds and compositions as cathepsin S inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2007-06-05 US claimed
US-7196099-B2 Compounds and compositions as cathepsin inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2007-03-27 US claimed
US-6977256-B2 Compounds and compositions as cathepsin S inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2005-12-20 US claimed
US-20050267044-A1 Novel compounds and compositions as cathepsin S inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2005-12-01 US claimed
US-20040192742-A1 Novel compounds and compositions as cathepsin inhibitors AVENTIS PHARMACEUTICALS INC. 2004-09-30 US claimed
EP-1446392-A1 OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THEM AS CATHEPSIN S INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2004-08-18 EP claimed
EP-1436255-A1 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2004-07-14 EP claimed
US-20030199506-A1 Novel compounds and compositions as cathepsin S inhibitors AXYS PHARMACEUTICALS INC. 2003-10-23 US claimed
WO-2003042197-A1 OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THEM AS CATHEPSIN S INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2003-05-22 WO claimed
WO-2003024924-A1 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2003-03-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050267044-A1 Novel compounds and compositions as cathepsin S inhibitors CTSS, CTSB, CTSE CTRB1 26/4885F2 3562/4885PRSS1 19/4885
US-10920170-B2 Fragrance mixtures containing tricyclo[5.2.1.0]-decane-8-ethyl ether CCT8, F8, TRPM8 CTRB1 1413/4885F2 180/4885PRSS1 3526/4885
US-20200063063-A1 FRAGRANCE MIXTURES CONTAINING TRICYCLO[5.2.1.0]-DECANE-8-ETHYL ETHER CCT8, F8, TRPM8 CTRB1 1413/4885F2 180/4885PRSS1 3526/4885
US-20040192742-A1 Novel compounds and compositions as cathepsin inhibitors CTSS, CTSB, CTSE CTRB1 24/4885F2 3329/4885PRSS1 29/4885
US-20030199506-A1 Novel compounds and compositions as cathepsin S inhibitors CTSS, CTSB, CTSE CTRB1 26/4885F2 3591/4885PRSS1 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.