Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14699548 | 0.85 | HTR2A (0.38) | MAPTHTR2ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14721884 | 0.85 | MEN1 (0.34) | MAPTSMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL14722203 | 0.82 | — | — | |
| SCHEMBL8027453 | 0.82 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14699541 | 0.71 | ALDH1A1 (0.32) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15900287 | 0.70 | ALDH1A1 (0.32) | MAPTLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14721914 | 0.70 | NUDT1 (0.31) | — | |
| SCHEMBL7168223 | 0.66 | HTR2A (0.30) | HTR2AHTR2CHTR2B | |
| SCHEMBL6904056 | 0.66 | HTR2B (0.46) | HRH1SLC6A4DRD2HTR6MAPT | |
| Hydrochloric Acid SCHEMBL5902888 | 0.65 | SLC6A2 (0.47) | HRH1SLC6A4DRD2HTR6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076757-A1 | MEDICINE FOR TREATING GASTROINTESTINAL DISORDER INCLUDING IRRITABLE BOWEL SYNDROME | LUNDEEN JAMES E | 2008-03-27 | — | — | US | disclosed |
| US-20070142367-A1 | METHOD AND MEDICINE FOR TREATING GASTROINTESTINAL DISORDER INCLUDING FECAL INCONTINENCE | LUNDEEN JAMES E | 2007-06-21 | — | — | US | disclosed |
| US-20060148783-A1 | Method and medicine for treating gastrointestinal disorder including fecal incontinence | SIR ISAAC NEWTON ENTERPRISES LLC | 2006-07-06 | — | — | US | disclosed |
| US-20060148784-A1 | Medicine for treating gastrointestinal disorder in a non-human mammal | LUNDEEN JAMES E | 2006-07-06 | — | — | US | disclosed |
| US-20060148782-A1 | Method and medicine for treating a mammal presenting urinary incontinence, urinary urgency, or both | SIR ISAAC NEWTON ENTERPRISES LLC | 2006-07-06 | — | — | US | disclosed |
| US-20060148781-A1 | Method and medicine for treating gastrointestinal disorder in a non-human mammal | SIR ISAAC NEWTON ENTERPRISES LLC | 2006-07-06 | — | — | US | disclosed |
| US-20060148786-A1 | Medicine for treating gastrointestinal disorder including irritable bowel syndrome | LUNDEEN JAMES E | 2006-07-06 | — | — | US | disclosed |
| US-20060148785-A1 | Medicine for treating gastrointestinal disorder including fecal incontinence | LUNDEEN JAMES E | 2006-07-06 | — | — | US | disclosed |
| US-20050113365-A1 | Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome | SIR ISAAC NEWTON ENTERPRISES LLC (US) | 2005-05-26 | — | — | US | disclosed |
| WO-1992018005-A1 | METHOD OF TREATING TRICHOTILLOMANIA AND ONYCHOPHAGIA | NATIONAL INSTITUTES OF HEALTH (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5008262-A | Administering clomipramine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1991-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148786-A1 | Medicine for treating gastrointestinal disorder including irritable bowel syndrome | SI, FABP2, HNMT | HRH1 38/4885SLC6A4 24/4885DRD2 81/4885 |
| US-20050113365-A1 | Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome | SI, TPH1, FABP2 | HRH1 42/4885SLC6A4 27/4885DRD2 71/4885 |
| US-20070142367-A1 | METHOD AND MEDICINE FOR TREATING GASTROINTESTINAL DISORDER INCLUDING FECAL INCONTINENCE | SI, HNMT, SLC10A2 | HRH1 208/4885SLC6A4 31/4885DRD2 351/4885 |
| US-20080076757-A1 | MEDICINE FOR TREATING GASTROINTESTINAL DISORDER INCLUDING IRRITABLE BOWEL SYNDROME | SI, FABP2, SLC10A2 | HRH1 71/4885SLC6A4 34/4885DRD2 170/4885 |
| US-20060148784-A1 | Medicine for treating gastrointestinal disorder in a non-human mammal | SI, FABP2, FABP6 | HRH1 76/4885SLC6A4 19/4885DRD2 314/4885 |
| US-20060148782-A1 | Method and medicine for treating a mammal presenting urinary incontinence, urinary urgency, or both | HNMT, CKMT1A; CKMT1B, OAT | HRH1 277/4885SLC6A4 64/4885DRD2 542/4885 |
| US-20060148785-A1 | Medicine for treating gastrointestinal disorder including fecal incontinence | SI, SLC10A2, HNMT | HRH1 272/4885SLC6A4 21/4885DRD2 586/4885 |
| US-20060148781-A1 | Method and medicine for treating gastrointestinal disorder in a non-human mammal | SI, FABP2, FABP6 | HRH1 69/4885SLC6A4 24/4885DRD2 259/4885 |
| US-20060148783-A1 | Method and medicine for treating gastrointestinal disorder including fecal incontinence | SI, SLC10A2, HNMT | HRH1 250/4885SLC6A4 25/4885DRD2 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.