Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574255 | 0.71 | LMNA (0.55) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL31316014 | 0.62 | MEN1 (0.37) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL254812 | 0.62 | LMNA (0.95) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL3948094 | 0.62 | LMNA (0.95) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL2555823 | 0.62 | LMNA (0.95) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL2052260 | 0.61 | SMN1; SMN2 (0.44) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL10070835 | 0.61 | LMNA (1.00) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL4408839 | 0.61 | LMNA (0.91) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL184087 | 0.61 | LMNA (0.91) | LMNASIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL11203977 | 0.61 | LMNA (1.00) | LMNASIGMAR1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1659154-B | Process for the preparation of amine stereoisomers | APSINTERM LLC | 2012-05-30 | — | — | CN | disclosed |
| CN-101613310-A | The preparation method of amine stereoisomers | APSINTERM LLC | 2009-12-30 | — | — | CN | disclosed |
| US-20080214870-A1 | Method of Preparing Amine Stereoisomers | HAN ZHENGXU | 2008-09-04 | — | — | US | disclosed |
| US-7332610-B2 | Method of preparing amine stereoisomers | APSINTERM LLC (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1497272-A4 | METHOD OF PREPARING AMINE STEREOISOMERS | APSINTERM LLC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-20060287539-A1 | Method of preparing amine stereoisomers | HAN ZHENGXU | 2006-12-21 | — | — | US | disclosed |
| US-7129378-B2 | Method of preparing amine stereoisomers | APSINTERM, LLC (US) | 2006-10-31 | — | — | US | disclosed |
| CN-1659154-A | Process for the preparation of amine stereoisomers | APSINTERM LLC (US) | 2005-08-24 | — | — | CN | disclosed |
| US-20050165240-A1 | Method of preparing amine stereoisomers | APSINTERM, LLC | 2005-07-28 | — | — | US | disclosed |
| EP-1497272-A2 | METHOD OF PREPARING AMINE STEREOISOMERS | Apsinterm, LLC. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003091207-A2 | METHOD OF PREPARING AMINE STEREOISOMERS | APSINTERM, LLC. (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165240-A1 | Method of preparing amine stereoisomers | SRM, TST, SMOX | LMNA 3417/4885SIGMAR1 411/4885MEN1 2372/4885 |
| US-20080214870-A1 | Method of Preparing Amine Stereoisomers | SRM, PNMT, SMS | LMNA 3396/4885SIGMAR1 476/4885MEN1 653/4885 |
| US-20060287539-A1 | Method of preparing amine stereoisomers | SRM, PNMT, SMS | LMNA 3396/4885SIGMAR1 476/4885MEN1 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.