Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31117953 | 0.75 | MAOA (0.47) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL21061397 | 0.70 | ADRB2 (0.41) | MAOAMAOBLMNAOPRL1OPRM1 | |
| SCHEMBL10787894 | 0.69 | MAOA (0.48) | MAOAMAOB | |
| SCHEMBL14315576 | 0.69 | MAOA (0.37) | MAOAMAOBTRPA1OPRL1OPRM1 | |
| SCHEMBL4904163 | 0.68 | OPRM1 (0.41) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL6672640 | 0.67 | MAOA (0.50) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL4206116 | 0.67 | OPRL1 (0.56) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL12349005 | 0.67 | MAOA (0.39) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL28495176 | 0.67 | LMNA (0.42) | MAOAMAOBTRPA1LMNAOPRL1 | |
| SCHEMBL27650244 | 0.67 | MAOA (0.50) | MAOAMAOBOPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058333-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | CATALANO JOHN G | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058333-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | CTSK, CTSS, CTSE | MAOA 2083/4885MAOB 2350/4885TRPA1 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.