Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703022 | 0.85 | PSIP1 (0.58) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL11211587 | 0.75 | ALDH1A1 (0.60) | MAPTPSIP1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2334382 | 0.74 | MAPT (0.56) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL11237701 | 0.74 | ALDH1A1 (0.63) | MAPTALDH1A1L3MBTL1HSD11B1SMN1; SMN2 | |
| SCHEMBL8940894 | 0.73 | MAPT (0.50) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL5128116 | 0.73 | ALDH1A1 (0.49) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL2454944 | 0.72 | PSIP1 (0.58) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL606282 | 0.71 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4ELMNAPKM | |
| SCHEMBL2616457 | 0.71 | CA2 (0.59) | MAPTPSIP1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL3329009 | 0.71 | PSIP1 (0.64) | MAPTPSIP1ALDH1A1HSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | MAPT 1653/4885PSIP1 3125/4885ALDH1A1 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.