Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28309494 | 0.83 | NPSR1 (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1L3MBTL1 | |
| SCHEMBL21376048 | 0.76 | TUBB4A (0.36) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL4337968 | 0.76 | NPC1 (0.45) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL29603104 | 0.76 | NCEH1 (0.40) | SMN1; SMN2RAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL16790012 | 0.75 | CYP1A2 (0.62) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL23066466 | 0.74 | ALDH1A1 (0.61) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL15330585 | 0.73 | ENPP2 (0.35) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL5607036 | 0.73 | CASP6 (0.41) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL174453 | 0.72 | CYP1A2 (0.54) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL1949784 | 0.72 | RAB9A (0.43) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | SMN1; SMN2 1729/4885RAB9A 2004/4885NPC1 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.