Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190628 | 0.82 | S1PR1 (0.44) | RAB9AMAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL8722639 | 0.76 | ALDH1A1 (0.46) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5475553 | 0.76 | CASP3 (0.52) | RAB9AMAPK1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL4337968 | 0.76 | NPC1 (0.45) | RAB9AMAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL10396259 | 0.76 | NPC1 (0.44) | RAB9ASMN1; SMN2TP53L3MBTL1ALDH1A1 | |
| SCHEMBL30584864 | 0.76 | NPC1 (0.44) | RAB9ASMN1; SMN2TP53L3MBTL1ALDH1A1 | |
| SCHEMBL6422966 | 0.73 | KDM4E (0.47) | RAB9AMAPK1SMN1; SMN2TP53MAPT | |
| SCHEMBL22455491 | 0.72 | CASP6 (0.33) | PPARACASP6 | |
| SCHEMBL21352408 | 0.72 | CASP6 (0.36) | PPARACASP6 | |
| SCHEMBL15332604 | 0.72 | LMNA (0.41) | SMN1; SMN2ALDH1A1PPARAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-30 | — | — | US | disclosed |
| EP-2507232-B1 | PROLINE DERIVATIVES | NATIONAL HEALTH RES INST (TW) | 2019-03-20 | — | — | EP | disclosed |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
| CN-102482269-B | Proline derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (CN) | 2015-07-29 | — | — | CN | disclosed |
| US-8415482-B2 | Proline derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-04-09 | — | — | US | disclosed |
| CN-102482269-A | Proline derivatives | NAT HEALTH RESEARCH INSTITUTES | 2012-05-30 | — | — | CN | disclosed |
| US-20110136799-A1 | PROLINE DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136799-A1 | PROLINE DERIVATIVES | PNISR, ARGLU1, PRR12 | RAB9A 291/4885MAPK1 3047/4885SMN1; SMN2 3364/4885 |
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | NFE2L2, KEAP1, NQO1 | RAB9A 2634/4885MAPK1 2637/4885SMN1; SMN2 4243/4885 |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, KEAP1, NQO1 | RAB9A 2634/4885MAPK1 2637/4885SMN1; SMN2 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.