SCHEMBL49848

SCHEMBL49848

Oc1ccc2nn[nH]c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLAU P00749 1/20 0.46
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
PDPK1 O15530 1/20 0.40
HSP90AB1 P08238 1/20 0.40
ENPP2 Q13822 1/20 0.39
ESR1 P03372 1/20 0.38
PKM P14618 2/20 0.38
CHEK1 O14757 1/20 0.38
PRKD3 O94806 1/20 0.38
PAK4 O96013 1/20 0.38
PDGFRA P16234 1/20 0.38
LTK P29376 1/20 0.38
MAP2K2 P36507 1/20 0.38
MAPK8 P45983 1/20 0.38
CDK8 P49336 1/20 0.38
RPS6KA3 P51812 1/20 0.38
PRKX P51817 1/20 0.38
NEK2 P51955 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL242787 0.83 ALDH1A1 (0.48) PLAUKDM4EALDH1A1HPGDPDPK1
SCHEMBL9939034 0.82 ESR1 (0.52) ESR1ABL1BCR
SCHEMBL9171831 0.81 ALDH1A1 (0.47) PLAUKDM4EALDH1A1HPGDPDPK1
Water SCHEMBL7451096 0.81 ALDH1A1 (0.47) PLAUKDM4EALDH1A1HPGDPDPK1
SCHEMBL2611832 0.74 KMT2A (0.43) KDM4EALDH1A1HPGDGAACBFB
SCHEMBL4104023 0.74 METAP2 (0.44) ALDH1A1PDPK1ESR1CHEK1FLT3
SCHEMBL735804 0.74 PRKCI (0.48) PLAUKDM4EALDH1A1HPGDPKM
SCHEMBL2005551 0.74 ALDH1A1 (0.46) KDM4EALDH1A1HPGDTSHRCBFB
SCHEMBL12871076 0.74
SCHEMBL2145072 0.74 NOS1 (0.39) PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763615-A Methods for the preparation of benzyloxy benzotriazole herbicidal agents AMERICAN CYANAMID COMPANY (US) 1998-06-09 US claimed
US-5686617-A RING CLOSURE, HYDROGENATION, ETHERIFICATION AMERICAN CYANAMID COMPANY (US) 1997-11-11 US claimed
US-20260133115-A1 MASS CYTOMETRY REAGENTS AND METHODS FOR SIGNAL AMPLIFICATION STANDARD BIOTOOLS CANADA INC. (CA) 2026-05-14 US disclosed
US-12540893-B2 Mass cytometry reagents and methods for signal amplification STANDARD BIOTOOLS CANADA INC. (CA) 2026-02-03 US disclosed
US-20250353855-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2025-11-20 US disclosed
CN-111454718-B Ultrasensitive chemiluminescent substrates for peroxidases 喜雅纳肯有限公司 2025-01-03 CN disclosed
CN-110208540-B Methods and compositions for the detection and treatment of preeclampsia 耶鲁大学 2024-02-09 CN disclosed
US-20230417755-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE CYANAGEN S R L (IT) 2023-12-28 US disclosed
EP-3686285-B1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE CYANAGEN S R L (IT) 2023-10-11 EP disclosed
US-11761964-B2 Ultra-sensitive chemiluminescent substrates for peroxidase CYANAGEN S.R.L. (IT) 2023-09-19 US disclosed
US-20230236105-A1 MASS CYTOMETRY REAGENTS AND METHODS FOR SIGNAL AMPLIFICATION STANDARD BIOTOOLS CANADA INC. (CA) 2023-07-27 US disclosed
US-5686617-A RING CLOSURE, HYDROGENATION, ETHERIFICATION AMERICAN CYANAMID COMPANY (US) 1997-11-11 US disclosed
CN-1149583-A Enderma agent receptor antagonist MERCK PATENT GMBH (DE) 1997-05-14 CN disclosed
EP-0758650-A1 Endothelin receptor antagonists MERCK PATENT GmbH (DE) 1997-02-19 EP disclosed
US-5428003-A Aryloxy benzotriazole herbicidal agents and methods for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1995-06-27 US disclosed
US-5324711-A Aryloxy benzotriazole herbicidal agents and methods for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1994-06-28 US disclosed
EP-0367242-A2 Aryloxy benzotriazole herbicidal agents and methods for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1990-05-09 EP disclosed
US-4297431-A POLYMERS OF ACRYLIC ESTERS AS OVERCOATS OR TIMING LAYERS FOR LIGHT SENSITIVE ELEMENTS POLAROID CORPORATION (US) 1981-10-27 US disclosed
US-4220694-A TRIAZOLE-COATED NEGATIVE ELECTRODE COLLECTOR HITACHI MAXELL, LTD. (JP) 1980-09-02 US disclosed
EP-0005823-A1 Leak-proof alkaline cell and its production Hitachi Maxell Ltd. (JP) 1979-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12540893-B2 Mass cytometry reagents and methods for signal amplification CD47, HLCS, SRMS PLAU 3843/4885KDM4E 3700/4885ALDH1A1 2358/4885
US-20260133115-A1 MASS CYTOMETRY REAGENTS AND METHODS FOR SIGNAL AMPLIFICATION SRMS, THOC2, TSPO PLAU 3768/4885KDM4E 4355/4885ALDH1A1 2892/4885
US-20250353855-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH PLAU 4058/4885KDM4E 3648/4885ALDH1A1 1719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.