Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Prednisolone Metazoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 13/20 | 0.62 |
| ▸ | PGR | P06401 | 4/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | AR | P10275 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | IL6 | P05231 | 1/20 | 0.62 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.62 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.62 |
| ▸ | GLUL | P15104 | 1/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone Metazoate SCHEMBL5483013 | 1.00 | PGR (0.68) | PGRHIF1ALMNANR3C1HSD17B10 | |
| Prednisolone Metazoate SCHEMBL2796992 | 1.00 | PGR (0.68) | PGRHIF1ALMNANR3C1HSD17B10 | |
| Prednisolone Metazoate SCHEMBL29379658 | 1.00 | PGR (0.68) | PGRHIF1ALMNANR3C1HSD17B10 | |
| Prednisolone Metazoate SCHEMBL1042225 | 1.00 | PGR (0.68) | PGRHIF1ALMNANR3C1HSD17B10 | |
| Prednisolone Metazoate SCHEMBL2916561 | 0.93 | PGR (0.70) | PGRHIF1ALMNANR3C1HSD17B10 | |
| Prednisolone Metazoate SCHEMBL5483006 | 0.92 | PGR (0.69) | PGRHIF1ALMNANR3C1HSD17B10 | |
| SCHEMBL28852123 | 0.88 | HIF1A (0.73) | PGRHIF1ALMNANR3C1HSD17B10 | |
| SCHEMBL11332832 | 0.88 | HIF1A (0.65) | PGRHIF1ALMNANR3C1HSD17B10 | |
| SCHEMBL27462874 | 0.87 | HIF1A (0.72) | PGRHIF1ALMNANR3C1HSD17B10 | |
| SCHEMBL9836047 | 0.86 | PGR (0.71) | PGRHIF1ALMNANR3C1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7438926-B2 | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure | ALZA CORPORATION (US) | 2008-10-21 | — | — | US | disclosed |
| EP-1335711-B1 | TRANSDERMAL DEVICE | ALZA CORP (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20020102292-A1 | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure | CORMIER MICHEL (US) | 2002-08-01 | — | — | US | disclosed |
| EP-0010056-B1 | CORTICOID SULFOPROPIONIC ACID ESTERS AND THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-08-24 | — | — | EP | disclosed |
| EP-0010056-A1 | Corticoid sulfopropionic acid esters and their salts, process for their preparation and pharmaceutical preparations containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-04-16 | — | — | EP | disclosed |