SCHEMBL5013704

SCHEMBL5013704

C[Si](C)(C)c1cc(Br)c(C=O)c(Br)c1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 1/20 0.36
ERN1 O75460 2/20 0.35
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL304092 0.73 ERN1 (0.41) PRKDCERN1LMNA
SCHEMBL3185596 0.72 ERN1 (0.50) PRKDCERN1LMNA
SCHEMBL31367053 0.70 ALDH1A1 (0.42) ERN1
SCHEMBL5426089 0.69 PGR (0.31) PRKDCERN1
SCHEMBL23658839 0.69 ERN1 (0.54) PRKDCERN1LMNA
SCHEMBL1726007 0.69 ERN1 (0.37) PRKDCERN1LMNA
SCHEMBL28302905 0.69 GAA (0.50) PRKDCERN1LMNA
SCHEMBL19616991 0.69 ERN1 (0.42) PRKDCERN1LMNA
SCHEMBL31353147 0.68 LMNA (0.41) PRKDCERN1LMNA
SCHEMBL3971701 0.67 ERN1 (0.37) ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240366629-A1 Porphyrin Complexes as Antidotes for Carbon Monoxide Exposure and Methods of Use for Same UNIV CALIFORNIA (US) 2024-11-07 US disclosed
EP-4395773-A1 PORPHYRIN COMPLEXES AS ANTIDOTES FOR CARBON MONOXIDE EXPOSURE AND METHODS OF USE FOR SAME The Regents of the University of California (US) 2024-07-10 EP disclosed
WO-2023034447-A9 PORPHYRIN COMPLEXES AS ANTIDOTES FOR CARBON MONOXIDE EXPOSURE AND METHODS OF USE FOR SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-04-20 WO disclosed
WO-2023034447-A1 PORPHYRIN COMPLEXES AS ANTIDOTES FOR CARBON MONOXIDE EXPOSURE AND METHODS OF USE FOR SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-09 WO disclosed
EP-3071631-B1 AMINE FUNCTIONALIZED POROUS NETWORK UNIV KING ABDULLAH SCI & TECH (SA) 2020-09-02 EP disclosed
US-9663627-B2 Amine functionalized porous network KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2017-05-30 US disclosed
EP-3071631-A1 AMINE FUNCTIONALIZED POROUS NETWORK King Abdullah University Of Science And Technology (SA) 2016-09-28 EP disclosed
CN-105916912-A Amine functionalized porous network 阿卜杜拉国王科技大学 2016-08-31 CN disclosed
US-20150148439-A1 AMINE FUNCTIONALIZED POROUS NETWORK KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2015-05-28 US disclosed
WO-2015077444-A1 AMINE FUNCTIONALIZED POROUS NETWORK KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2015-05-28 WO disclosed
US-7417142-B2 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, INC. (US) 2008-08-26 US disclosed
US-20060030718-A1 Cobalt-based catalysts for the cyclization of alkenes UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2006-02-09 US disclosed
US-20050124596-A1 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2005-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060030718-A1 Cobalt-based catalysts for the cyclization of alkenes PPOX, HCCS, ICOSLG PRKDC 3897/4885ERN1 4454/4885LMNA 1845/4885
US-20240366629-A1 Porphyrin Complexes as Antidotes for Carbon Monoxide Exposure and Methods of Use for Same MB, HMBS, HMOX2 PRKDC 3090/4885ERN1 4460/4885LMNA 1804/4885
US-20050124596-A1 Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same PPOX, PPIF, HMBS PRKDC 1489/4885ERN1 3635/4885LMNA 4475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.