Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10056749 | 1.00 | ABCB1 (0.53) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL502387 | 1.00 | ABCB1 (0.53) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL14141132 | 0.89 | CYP1A2 (0.50) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL30464792 | 0.89 | KDM4E (0.64) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL14139923 | 0.88 | ABCB1 (0.52) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL4404099 | 0.88 | ABCB1 (0.52) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL1779128 | 0.86 | MAPT (0.47) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL1779129 | 0.86 | MAPT (0.47) | ABCB1KDM4EGAAKMT2AMEN1 | |
| SCHEMBL10580837 | 0.85 | POLB (0.47) | KDM4EGAAKMT2AMEN1LMNA | |
| SCHEMBL17572179 | 0.85 | MEN1 (0.52) | ABCB1KDM4EGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592493-B | Preparation method of mefenpyr-diethyl | 上海赫腾精细化工有限公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-111592493-A | Preparation method of mefenpyr-diethyl | 上海赫腾精细化工有限公司 | 2020-08-28 | — | — | CN | disclosed |
| US-8106085-B2 | Indoline-substituted pyrazoline derivatives, their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-01-31 | — | — | US | disclosed |
| US-7994200-B2 | Central nervous system disorders; respiratory system disorders; sexual or reproductive disorders; eating disorders; antidiabetic agents; cardiovascular disorders; anticancer agents | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-08-09 | — | — | US | disclosed |
| US-20100099712-A1 | SUBSTITUTED PYRAZOLINE COMPOUNDS WITH ACAT INHIBITION ACTIVITY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-04-22 | — | — | US | disclosed |
| US-20090131497-A1 | INDOLINE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-05-21 | — | — | US | disclosed |
| US-20090054509-A1 | Octahydropentalene-Substituted Pyrazoline Derivatives, Their Prepartion and Use as Medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-02-26 | — | — | US | disclosed |
| US-20080293797-A1 | Cycloalkane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-11-27 | — | — | US | disclosed |
| US-20080287517-A1 | Pyrazole Derivatives as Cb1 Modulators | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
| US-20080269201-A1 | Azepane- or Azocane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-10-30 | — | — | US | disclosed |
| EP-1910344-A2 | INDOLINE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios del Dr. Esteve S.A. (ES) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910339-A2 | AZEPANE- OR AZOCANE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios del Dr. Esteve S.A. (ES) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009722-A1 | OCTAHYDROPENTALENE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009723-A2 | AZEPANE- OR AZOCANE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009721-A2 | INDOLINE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007010217-A1 | PYRAZOLE DERIVATIVES AS CBl MODULATORS | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009724-A2 | CYCLOALKANE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2007-01-25 | — | — | WO | disclosed |
| US-5159086-A | Cyclization in presence of inorganic base; aromatization | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |
| EP-0439835-A2 | Process for the preparation of pyrazolecarboxylic acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-07 | — | — | EP | disclosed |
| EP-0307676-A1 | Process for the preparation of 1-aryl-pyrazole-3-carbon acid esters | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293797-A1 | Cycloalkane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments | PIGO, BDKRB2, FPR1 | ABCB1 363/4885KDM4E 4558/4885GAA 2337/4885 |
| US-20080269201-A1 | Azepane- or Azocane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments | AZI2, CYP3A43, ALPI | ABCB1 147/4885KDM4E 1365/4885GAA 1858/4885 |
| US-20080287517-A1 | Pyrazole Derivatives as Cb1 Modulators | CNR1, CNR2, HTR3C | ABCB1 1092/4885KDM4E 772/4885GAA 4497/4885 |
| US-20100099712-A1 | SUBSTITUTED PYRAZOLINE COMPOUNDS WITH ACAT INHIBITION ACTIVITY | ACAT2, ACAT1, LCAT | ABCB1 578/4885KDM4E 2895/4885GAA 68/4885 |
| US-20090054509-A1 | Octahydropentalene-Substituted Pyrazoline Derivatives, Their Prepartion and Use as Medicaments | CYP11B2, OTC, OAT | ABCB1 182/4885KDM4E 4099/4885GAA 3286/4885 |
| US-20090131497-A1 | INDOLINE-SUBSTITUTED PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | IDO1, PIR, INMT | ABCB1 727/4885KDM4E 2806/4885GAA 3643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.