Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14275213 | 0.86 | KDM1A (0.42) | MAPTGFERALDH1A1GAAKDM4E | |
| SCHEMBL14305878 | 0.81 | MAPT (0.43) | MAPTSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5057748 | 0.78 | KIF11 (0.43) | MAPTLMNAGFERSLC6A2SLC6A4 | |
| SCHEMBL14275236 | 0.76 | SLC6A2 (0.40) | MAPTLMNAGFERSLC6A2SLC6A4 | |
| SCHEMBL28765011 | 0.75 | RIPK1 (0.41) | MAPTLMNAGFERSLC6A2SLC6A4 | |
| SCHEMBL14305875 | 0.74 | ALDH1A1 (0.44) | MAPTSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5061808 | 0.69 | GFER (0.43) | MAPTLMNAGFERSLC6A2SLC6A4 | |
| SCHEMBL11063972 | 0.64 | ALOX5 (0.42) | FADS1L3MBTL1ALOX5MEN1KMT2A | |
| SCHEMBL29458508 | 0.64 | FADS1 (0.44) | MAPTLMNAGFERSLC6A2SLC6A4 | |
| SCHEMBL2864527 | 0.62 | KDM1A (0.53) | MAPTGFERALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045492-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-02-21 | — | — | US | disclosed |
| US-20080045492-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-02-21 | — | — | US | disclosed |
| US-20080045492-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-02-21 | — | — | US | disclosed |
| EP-1831176-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006068933-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045492-A1 | Mitotic Kinesin Inhibitors | KIF5B, KIF2C, KIF23 | MAPT 214/4885LMNA 3156/4885GFER 4746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.