Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441710 | 0.77 | PGK1 (0.44) | IDO1HTR1DMAPTMEN1KMT2A | |
| SCHEMBL14959898 | 0.76 | HTR1D (0.56) | HRH3HTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL27995904 | 0.75 | HRH3 (0.54) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL1316919 | 0.75 | HTR1D (0.48) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL9170599 | 0.74 | ALDH1A1 (0.36) | IDO1ALDH1A1TSHR | |
| SCHEMBL16612059 | 0.74 | ALDH1A1 (0.46) | IDO1ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL28489168 | 0.73 | HRH3 (0.41) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL327084 | 0.73 | HRH3 (0.41) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL5351172 | 0.72 | PGK1 (0.37) | — | |
| SCHEMBL5352095 | 0.71 | IDO1 (0.38) | IDO1MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 195 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105520930-A | Applications of a class of flavane compounds in prevention or treatment of melanoma | INST MATERIA MEDICA CAMS | 2016-04-27 | — | — | CN | claimed |
| CN-118851958-A | Acyl sulfonamide compound, preparation method and application thereof | 中国医学科学院药物研究所 | 2024-10-29 | — | — | CN | disclosed |
| WO-2024089170-A1 | ANTIBACTERIAL COMPOUNDS | Janssen Sciences Ireland Unlimited Company (IE) | 2024-05-02 | — | — | WO | disclosed |
| US-20230151054-A1 | SULFUR EXTRUSION FROM DISULFIDES BY CARBENES | Universität Heidelberg (DE) | 2023-05-18 | — | — | US | disclosed |
| US-20230151054-A1 | SULFUR EXTRUSION FROM DISULFIDES BY CARBENES | Universität Heidelberg (DE) | 2023-05-18 | — | — | US | disclosed |
| US-11618763-B2 | Selective valorization of biomass sugars | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-04-04 | — | — | US | disclosed |
| US-11618744-B2 | Benzoimidazoles as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2023-04-04 | — | — | US | disclosed |
| US-20220218713-A1 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES | HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) | 2022-07-14 | — | — | US | disclosed |
| EP-3750896-B1 | CHIRAL TETRADENTATE LIGAND, METHOD FOR PRODUCING SAME AND TRANSITION METAL COMPLEX OF SAID CHIRAL TETRADENTATE LIGAND | TAKASAGO PERFUMERY CO LTD (JP) | 2022-06-29 | — | — | EP | disclosed |
| EP-3901135-A1 | SULFUR EXTRUSION FROM DISULFIDES BY CARBENES | Universität Heidelberg (DE) | 2021-10-27 | — | — | EP | disclosed |
| EP-0669949-A1 | TERTIARY AMINE DERIVATIVES AS COMPONENTS OF POLYMER FORMING SYSTEMS | HENKEL CORPORATION (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5444127-A | Urea, thiourea, guanidine derivatives, curing agents for epoxy resins, odorless, low temperature | HENKEL CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| US-5420128-A | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| WO-1994009051-A1 | TERTIARY AMINE DERIVATIVES AS COMPONENTS OF POLYMER FORMING SYSTEMS | HENKEL CORPORATION (US) | 1994-04-28 | — | — | WO | disclosed |
| EP-0503099-A1 | PYRIMIDINE DERIVATIVE, PRODUCTION THEREOF, AND ANDROGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |
| CN-1060844-A | Pyrimidine derivatives, its method for making and inhibitor for androgen | OTSUKA PHARMA CO LTD (JP) | 1992-05-06 | — | — | CN | disclosed |
| EP-0014745-B1 | CURING AGENT FOR POLYEPOXIDES, CURABLE EPOXY RESIN COMPOSITIONS, HARDENED PRODUCTS THEREFROM AND PROCESS FOR CURING A POLYEPOXIDE | DIAMOND SHAMROCK CORPORATION (US) | 1983-05-25 | — | — | EP | disclosed |
| EP-0075827-A2 | Polyepoxide curing by polymercaptans plus catalytic co-curing agents | DIAMOND SHAMROCK CHEMICALS COMPANY (US) | 1983-04-06 | — | — | EP | disclosed |
| EP-0014745-A1 | Curing agent for polyepoxides, curable epoxy resin compositions, hardened products therefrom and process for curing a polyepoxide | DIAMOND SHAMROCK CORPORATION (US) | 1980-09-03 | — | — | EP | disclosed |
| US-4177173-A | INFUSIBLE FILMS, CASTINGS OR ADHESIVES | DIAMOND SHAMROCK CORPORATION (US) | 1979-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11618744-B2 | Benzoimidazoles as prolyl hydroxylase inhibitors | P4HA1, PAH, EGLN3 | HRH3 264/4885RAPGEF4 3349/4885IDO1 256/4885 |
| US-20220218713-A1 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES | FABP2, PLEC, FABP6 | HRH3 1173/4885RAPGEF4 2615/4885IDO1 1036/4885 |
| US-11618763-B2 | Selective valorization of biomass sugars | GALE, FBP1, GNE | HRH3 4538/4885RAPGEF4 4330/4885IDO1 996/4885 |
| US-20230151054-A1 | SULFUR EXTRUSION FROM DISULFIDES BY CARBENES | TST, CBS, CTH | HRH3 3089/4885RAPGEF4 3962/4885IDO1 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.