Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649328 | 0.98 | GABRA1 (0.36) | GABRA1GABRB2ALDH1A1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL5127807 | 0.80 | TAAR1 (0.40) | ALDH1A1APOBEC3AAPOBEC3GTAAR1KDM4E | |
| SCHEMBL4649846 | 0.78 | TAAR1 (0.41) | ALDH1A1APOBEC3AAPOBEC3GTAAR1KDM4E | |
| SCHEMBL3667640 | 0.72 | CALM1 (0.44) | GABRA1GABRB2ALDH1A1TSHRMAPT | |
| SCHEMBL25260415 | 0.71 | CYP1A2 (0.47) | ACHETDP1TSHR | |
| Bromide SCHEMBL5117868 | 0.71 | ALDH1A1 (0.41) | ALDH1A1ACHEKDM4ETDP1TSHR | |
| Bromide SCHEMBL29515277 | 0.69 | SNCA (0.38) | GABRA1GABRB2ALDH1A1TAAR1ACHE | |
| SCHEMBL4649332 | 0.69 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1TSHRMAPT | |
| Bromide SCHEMBL6122965 | 0.69 | KDM4E (0.56) | ALDH1A1APOBEC3AAPOBEC3GACHEKDM4E | |
| SCHEMBL1453966 | 0.69 | GABRA1 (0.46) | GABRA1GABRB2ALDH1A1TAAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312268-A1 | Substituted tricyclic piperidone compounds | GRUENENTHAL GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312268-A1 | Substituted tricyclic piperidone compounds | ITCH, OPRD1, OPRK1 | ACHE 181/4885GABRA1 306/4885GABRB2 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.