Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 9/20 | 0.43 |
| ▸ | CES1 | P23141 | 9/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21384024 | 0.82 | MARS1 (0.43) | AURKARPS6KB1MAPTKMT2AHTT | |
| SCHEMBL5149093 | 0.80 | L3MBTL1 (0.48) | CES2CES1MAPTHTTALDH1A1 | |
| SCHEMBL21383951 | 0.73 | PTGER4 (0.43) | AURKARPS6KB1KMT2ALMNASAE1 | |
| SCHEMBL22479641 | 0.72 | LMNA (0.50) | AURKARPS6KB1MAPTKMT2ALMNA | |
| SCHEMBL21395273 | 0.72 | LMNA (0.47) | AURKARPS6KB1LMNASAE1UBA2 | |
| SCHEMBL21383972 | 0.71 | PTGS2 (0.44) | MAPTKMT2AHTTLMNASAE1 | |
| SCHEMBL6237236 | 0.70 | ALDH1A1 (0.60) | MAPTKMT2AHTTALDH1A1SMN1; SMN2 | |
| Benzil SCHEMBL7112388 | 0.70 | CES2 (0.78) | CES2CES1MAPTKMT2AALDH1A1 | |
| SCHEMBL7803958 | 0.69 | HSD17B10 (0.45) | MAPTKMT2ALMNASAE1UBA2 | |
| Benzil SCHEMBL337491 | 0.68 | CES2 (0.74) | CES2CES1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265120-B2 | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2007-09-04 | — | — | US | disclosed |
| US-20050222159-A1 | Pyrazine derivatives and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222159-A1 | Pyrazine derivatives and pharmaceutical use thereof | ADORA2A, HTR5A, ADORA1 | CES2 2400/4885CES1 3316/4885AURKA 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.