Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | IDE | P14735 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456107 | 1.00 | HLCS (0.64) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL5821183 | 1.00 | HLCS (0.64) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL5817718 | 0.99 | HLCS (0.63) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL6159219 | 0.97 | HLCS (0.60) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL5804916 | 0.97 | TDP1 (0.61) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL30800274 | 0.97 | TDP1 (0.61) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL30337427 | 0.94 | HLCS (0.58) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL15353872 | 0.89 | TDP1 (0.64) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL31065870 | 0.89 | HLCS (0.58) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL739034 | 0.89 | TDP1 (0.63) | HLCSTDP1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566494-B1 | CXCR4 RECEPTOR COMPOUNDS | ACER THERAPEUTICS INC (US) | 2017-11-29 | — | — | EP | disclosed |
| US-20160159861-A1 | APJ Receptor Compounds | ANCHOR THERAPEUTICS, INC. (US) | 2016-06-09 | — | — | US | disclosed |
| US-9155795-B2 | CXCR4 receptor compounds | ANCHOR THERAPEUTICS, INC. (US) | 2015-10-13 | — | — | US | disclosed |
| US-9096646-B2 | CXCR4 receptor compounds | ANCHOR THERAPEUTICS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20150011466-A1 | APJ Receptor Compounds | ANCHOR THERAPEUTICS INC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20130210709-A1 | CXCR4 Receptor Compounds | ACER THERAPEUTICS INC. | 2013-08-15 | — | — | US | disclosed |
| US-20130005944-A1 | CXCR4 Receptor Compounds | ACER THERAPEUTICS INC. | 2013-01-03 | — | — | US | disclosed |
| US-20120028888-A1 | APJ RECEPTOR COMPOUNDS | ANCHOR THERAPEUTICS, INC. | 2012-02-02 | — | — | US | disclosed |
| US-20110301087-A1 | CRF1 RECEPTOR COMPOUNDS | ANCHOR THERAPEUTICS, INC. | 2011-12-08 | — | — | US | disclosed |
| US-20110300167-A1 | CXCR5 RECEPTOR COMPOUNDS | ANCHOR THERAPEUTICS, INC. | 2011-12-08 | — | — | US | disclosed |
| US-20110294738-A1 | PTHR1 RECEPTOR COMPOUNDS | ANTHOR THERAPEUTICS, INC. | 2011-12-01 | — | — | US | disclosed |
| WO-2010053547-A2 | CXCR5 RECEPTOR COMPOUNDS | ANCHOR THERAPEUTICS, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294738-A1 | PTHR1 RECEPTOR COMPOUNDS | PTH1R, MC1R, CASR | HLCS 4297/4885TDP1 2582/4885MEN1 398/4885 |
| US-20150011466-A1 | APJ Receptor Compounds | APLNR, AP1G1, AP2B1 | HLCS 1990/4885TDP1 4639/4885MEN1 4240/4885 |
| US-20120028888-A1 | APJ RECEPTOR COMPOUNDS | APLNR, AP1G1, AP2B1 | HLCS 2179/4885TDP1 4531/4885MEN1 4292/4885 |
| US-20130005944-A1 | CXCR4 Receptor Compounds | CXCL12, CXCR4, CCR5 | HLCS 3055/4885TDP1 3953/4885MEN1 2487/4885 |
| US-20110300167-A1 | CXCR5 RECEPTOR COMPOUNDS | CXCR5, CXCR1, CCR5 | HLCS 1701/4885TDP1 3702/4885MEN1 3324/4885 |
| US-20130210709-A1 | CXCR4 Receptor Compounds | CXCR4, CXCL12, SDF4 | HLCS 2973/4885TDP1 4462/4885MEN1 3835/4885 |
| US-20110301087-A1 | CRF1 RECEPTOR COMPOUNDS | CRHR1, CRH, CRHR2 | HLCS 4474/4885TDP1 2784/4885MEN1 4518/4885 |
| US-20160159861-A1 | APJ Receptor Compounds | APLNR, AP1G1, AP2B1 | HLCS 1990/4885TDP1 4639/4885MEN1 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.