SCHEMBL522987

SCHEMBL522987

OCc1ccc(CO)c(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.43
EGFR P00533 1/20 0.43
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 1/20 0.41
IDO1 P14902 3/20 0.41
TTR P02766 1/20 0.41
TP53 P04637 1/20 0.37
MAPT P10636 1/20 0.37
XBP1 P17861 1/20 0.37
HTT P42858 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP3A4 P08684 2/20 0.37
TSHR P16473 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
ERCC1 P07992 1/20 0.36
ERCC4 Q92889 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7164454 0.85 CYP4F2 (0.40) EGFRNPC1RAB9ASMN1; SMN2HPGD
SCHEMBL30442346 0.85 CYP4F2 (0.40) EGFRNPC1RAB9ASMN1; SMN2HPGD
SCHEMBL17013472 0.85 CSNK2A1 (0.52) CYP3A4PNMTTAAR1
SCHEMBL8772771 0.85 TRPA1 (0.43) SMN1; SMN2IDO1TSHRCYP1A2MAPK1
SCHEMBL12900227 0.85 RECQL (0.39) RECQLEGFRNPC1RAB9ASMN1; SMN2
SCHEMBL30989341 0.85 RECQL (0.39) RECQLEGFRNPC1RAB9ASMN1; SMN2
SCHEMBL15778552 0.85 LMNA (0.43) RECQLEGFRNPC1RAB9ASMN1; SMN2
SCHEMBL16958596 0.81 ALOX5 (0.40) RECQLNPC1RAB9ASMN1; SMN2HPGD
SCHEMBL31621229 0.81 RECQL (0.43) RECQLEGFRNPC1RAB9ASMN1; SMN2
SCHEMBL92905 0.80 IDO1 (0.58) RECQLSMN1; SMN2IDO1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11827612-B2 Hydroxamic acid derivative, method for producing same and use thereof INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2023-11-28 US disclosed
US-11827612-B2 Hydroxamic acid derivative, method for producing same and use thereof INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2023-11-28 US disclosed
US-20220033369-A1 HYDROXAMIC ACID DERIVATIVE, METHOD FOR PRODUCING SAME AND USE THEREOF INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-02-03 US disclosed
WO-2021052353-A1 HYDROXAMIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 中国医学科学院医药生物技术研究所 2021-03-25 WO disclosed
US-8980904-B2 Heterocyclic substituted pyrimidine compound Xuanzhu Pharma Co., Ltd. (CN) 2015-03-17 US disclosed
US-20140288063-A1 Heterocyclic Substituted Pyrimidine Compound Xuanzhu Pharma Co., Ltd. (CN) 2014-09-25 US disclosed
EP-2415741-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2012-02-08 EP disclosed
EP-2415742-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR Sumitomo Chemical Company, Limited (JP) 2012-02-08 EP disclosed
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-12 US disclosed
EP-2033944-A1 PROCESS FOR PRODUCTION OF HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2009-03-11 EP disclosed
EP-1978008-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2008-10-08 EP disclosed
US-20080070154-A1 DECOMPOSABLE RESIN COMPOSITION AND PATTERN-FORMING MATERIAL INCLUDING THE SAME FUJIFILM CORPORATION (JP) 2008-03-20 US disclosed
US-20080070154-A1 DECOMPOSABLE RESIN COMPOSITION AND PATTERN-FORMING MATERIAL INCLUDING THE SAME FUJIFILM CORPORATION (JP) 2008-03-20 US disclosed
EP-1894953-A2 Decomposable resin composition and pattern-forming material including the same FUJIFILM Corporation (JP) 2008-03-05 EP disclosed
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-09-13 US disclosed
EP-1783108-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
US-5310858-A Process for preparing polymers of p-xylylene from p-xylylene diesters HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-10 US disclosed
EP-0554675-A1 Process for the preparation of para-xylylene polymers and derivatives thereof HOECHST AKTIENGESELLSCHAFT (DE) 1993-08-11 EP disclosed
US-4031163-A CROSS LINKING SELF-EXTINGUISHING, THERMAL STABILITY DYNAMIT NOBEL AKTIENGESELLSCHAFT (DT) 1977-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND ADH1A, ADH1C, ADH5 RECQL 4728/4885EGFR 2808/4885NPC1 2661/4885
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent ADH1A, ADH1C, CYP4A11 RECQL 2285/4885EGFR 1289/4885NPC1 2782/4885
US-20140288063-A1 Heterocyclic Substituted Pyrimidine Compound PDE3B, PDE5A, PDE3A RECQL 320/4885EGFR 3450/4885NPC1 3718/4885
US-20220033369-A1 HYDROXAMIC ACID DERIVATIVE, METHOD FOR PRODUCING SAME AND USE THEREOF HACL2, NAAA, LCT RECQL 3451/4885EGFR 3685/4885NPC1 2740/4885
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR ADH1A, ADH1C, ADH5 RECQL 4464/4885EGFR 3137/4885NPC1 3195/4885
US-11827612-B2 Hydroxamic acid derivative, method for producing same and use thereof HACL2, NAAA, LCT RECQL 3451/4885EGFR 3685/4885NPC1 2740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.