Cadaverine Tartrate — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 ESR1 ESR2 GABRA1 GABRB1 GABRG2 GBA1 HRH1 HTR1D HTR2A OPRD1 OPRK1 OPRM1 SLC6A2 SLC6A3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ADRB2 known ✓	P07550	1/20	0.43

▸	HTR1D known ✓	P28221	1/20	0.43

▸	HTR2A known ✓	P28223	1/20	0.40

▸	LMNA	P02545	1/20	0.45

▸	TP53	P04637	1/20	0.45

▸	RXFP1	Q9HBX9	1/20	0.45

▸	ICMT	O60725	2/20	0.42

▸	KDM4E	B2RXH2	2/20	0.41

▸	HPGD	P15428	1/20	0.41

▸	HSD17B10	Q99714	1/20	0.41

▸	ALDH1A1	P00352	1/20	0.41

▸	SNCA	P37840	1/20	0.41

▸	SPR	P35270	1/20	0.40

▸	MPO	P05164	1/20	0.40

▸	HASPIN	Q8TF76	3/20	0.39

▸	MEN1	O00255	2/20	0.39

▸	KMT2A	Q03164	2/20	0.39

▸	NQO2	P16083	1/20	0.38

▸	MTNR1A	P48039	1/20	0.38

▸	MTNR1B	P49286	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5241306	0.88	ADRB2 (0.54)	LMNATP53RXFP1ADRB2HTR1D
Cadaverine Tartrate SCHEMBL3697458	0.86	LMNA (0.46)	LMNATP53RXFP1ADRB2ICMT
SCHEMBL5239371	0.84	ADRB2 (0.52)	LMNATP53RXFP1ADRB2HTR1D
SCHEMBL7828706	0.80	LMNA (0.56)	LMNATP53RXFP1ICMTKDM4E
SCHEMBL5923660	0.79	ADRB2 (0.64)	LMNATP53RXFP1ADRB2HTR1D
Hydrochloric Acid SCHEMBL16592500	0.78	ADRB2 (0.62)	LMNATP53RXFP1ADRB2HTR1D
SCHEMBL7734844	0.77	KDM4E (0.51)	LMNATP53RXFP1ADRB2HTR1D
SCHEMBL21266309	0.77	ALDH1A1 (0.48)	LMNATP53RXFP1ICMTKDM4E
SCHEMBL7734107	0.76	ICMT (0.50)	LMNATP53RXFP1ADRB2HTR1D
SCHEMBL7723955	0.74	KDM4E (0.48)	LMNATP53RXFP1ADRB2HTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20120122948-A1	3-ALKYL-5-FLUOROINDOLE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS	UNIVERSITE LIBRE DE BEUXELLES (BE)	2012-05-17	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120122948-A1	3-ALKYL-5-FLUOROINDOLE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS	MPO, SERPINB1, MAOA	ADRB2 450/4885HTR1D 177/4885HTR2A 145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.