Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 8/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262363 | 0.87 | P2RX7 (0.40) | P2RX7LMNAMEN1RAB9AKMT2A | |
| SCHEMBL5260602 | 0.81 | CNR1 (0.44) | — | |
| SCHEMBL5260594 | 0.80 | RAB9A (0.44) | LMNAMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5260359 | 0.77 | KMT2A (0.40) | MEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5262392 | 0.74 | SLC6A9 (0.53) | MEN1RAB9AKMT2ASMN1; SMN2SLC6A9 | |
| SCHEMBL5264063 | 0.73 | PIM1 (0.44) | P2RX7RAB9A | |
| SCHEMBL5262202 | 0.73 | TRPV1 (0.45) | P2RX7 | |
| SCHEMBL5264103 | 0.72 | CYP1A2 (0.58) | LMNAMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5264331 | 0.72 | LMNA (0.52) | LMNAMEN1KMT2ASMN1; SMN2SLC6A9 | |
| SCHEMBL5263576 | 0.71 | RAB9A (0.46) | LMNAMEN1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |