Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | THRA | P10827 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667397 | 0.91 | THRA (0.57) | THRBTHRAL3MBTL1KMT2ASMPD1 | |
| SCHEMBL4666452 | 0.87 | CYSLTR2 (0.54) | THRBTHRAL3MBTL1KMT2ASMPD1 | |
| SCHEMBL5270021 | 0.85 | THRB (0.63) | THRBTHRAL3MBTL1KMT2ASMPD1 | |
| SCHEMBL4266606 | 0.82 | HPGD (0.50) | THRBTHRAL3MBTL1KMT2AMAPT | |
| SCHEMBL8955658 | 0.82 | CYSLTR2 (0.63) | THRBTHRAL3MBTL1SMPD1PLA2G4B | |
| SCHEMBL27586299 | 0.82 | THRA (0.78) | THRBTHRAKMT2ASMPD1PLA2G4B | |
| SCHEMBL11112469 | 0.82 | KMT2A (0.50) | THRBTHRAL3MBTL1KMT2ASMPD1 | |
| SCHEMBL204170 | 0.82 | CYSLTR2 (0.54) | L3MBTL1KMT2ASMPD1CYSLTR2CYSLTR1 | |
| SCHEMBL3829470 | 0.81 | L3MBTL1 (0.68) | THRBTHRAL3MBTL1MAPTNPC1 | |
| SCHEMBL5273048 | 0.81 | THRA (0.58) | THRBTHRAL3MBTL1SMPD1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420771-B9 | USE OF TRIFLUOROACETYL ALKYL-SUBSTITUTED PHENYL DERIVATIVES, PHENOL DERIVATIVES, AND BENZOYL DERIVATIVES IN THE TREATMENT AND/OR PROPHYLAXIS OF OBESITY AND ACCOMPANYING DISEASES AND/OR SECONDARY DISEASES | SOLVAY PHARM GMBH (DE) | 2007-10-17 | — | — | EP | disclosed |
| EP-1420771-B1 | USE OF TRIFLUOROACETYL ALKYL-SUBSTITUTED PHENYL DERIVATIVES, PHENOL DERIVATIVES, AND BENZOYL DERIVATIVES IN THE TREATMENT AND/OR PROPHYLAXIS OF OBESITY AND ACCOMPANYING DISEASES AND/OR SECONDARY DISEASES | SOLVAY PHARM GMBH (DE) | 2006-09-06 | — | — | EP | disclosed |
| US-6930207-B2 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | SOLVAY PHARMACEUTICAL GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040214901-A1 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | SOLVAY PHARMACEUTICALS GMBH (DE) | 2004-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214901-A1 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | PNLIP, LIPC, CEL | THRB 1332/4885THRA 1949/4885L3MBTL1 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.