Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876057 | 0.80 | RAB9A (0.47) | RAB9ANPC1MAPTALDH1A1LMNA | |
| SCHEMBL30461135 | 0.78 | RAB9A (0.69) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL30461136 | 0.78 | RAB9A (0.69) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6738366 | 0.75 | TSHR (0.76) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4585369 | 0.75 | IDO1 (0.56) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7137082 | 0.75 | GUSB (0.55) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| 4-Nitrobenzoic Acid SCHEMBL17460232 | 0.75 | TDP1 (0.55) | MAPTALDH1A1CSNK2A1TDP1 | |
| SCHEMBL6231939 | 0.74 | RAB9A (0.60) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2643483 | 0.74 | NPC1 (0.67) | IDO1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL29496950 | 0.74 | NPC1 (0.67) | IDO1RAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078163-B2 | Processes for the synthesis of substituted urea compounds | Bial-Portela & Cª, S.A. (PT) | 2021-08-03 | — | — | US | disclosed |
| US-11078163-B2 | Processes for the synthesis of substituted urea compounds | Bial-Portela & Cª, S.A. (PT) | 2021-08-03 | — | — | US | disclosed |
| US-11046654-B2 | Urea compounds and their use as enzyme inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2021-06-29 | — | — | US | disclosed |
| US-11046654-B2 | Urea compounds and their use as enzyme inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2021-06-29 | — | — | US | disclosed |
| CN-105934431-B | Process for preparing substituted urea compounds | 比亚尔-珀特拉和CA股份公司 | 2020-11-17 | — | — | CN | disclosed |
| US-20200255412-A1 | Imidazolecarboxamides and Their Use as FAAH Inhibitors | BIAL-PORTELA & CA SA (PT) | 2020-08-13 | — | — | US | disclosed |
| US-20200140391-A1 | Processes for the Synthesis of Substituted Urea Compounds | BIAL-PORTELA & CA, S.A. (PT) | 2020-05-07 | — | — | US | disclosed |
| US-20200140391-A1 | Processes for the Synthesis of Substituted Urea Compounds | BIAL-PORTELA & CA, S.A. (PT) | 2020-05-07 | — | — | US | disclosed |
| EP-3097082-B1 | PROCESSES FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL PORTELA & CA SA (PT) | 2019-10-02 | — | — | EP | disclosed |
| EP-3097082-B1 | PROCESSES FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL PORTELA & CA SA (PT) | 2019-10-02 | — | — | EP | disclosed |
| US-6426345-B1 | PHOSPHODIESTERASE INHIBITORS; ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-30 | — | — | US | disclosed |
| WO-2002050091-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
| US-6403302-B1 | DOUBLE HELICAL NUCLEIC ACID COMPRISING COMPLEMENTARY STRANDS AND OLIGONUCLEOTIDE BOUND TO TARGET SEQUENCE WITHIN; GENETIC ENGINEERING; DIAGNOSING GENE DISORDERS; ANTIPARALLEL ORIENTATION; NON-DENATURING | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-06-11 | — | — | US | disclosed |
| CN-1250776-A | Heterodicyclic compound derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-04-19 | — | — | CN | disclosed |
| CN-1051548-C | Heterobicyclic derivatives, pharmaceutical compositions containing them, process for preparing them and their use | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-04-19 | — | — | CN | disclosed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| EP-0920867-A1 | Pyrido[2,3-a]pyrazine derivatives as PDE-IV and TNF inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-06-09 | — | — | EP | disclosed |
| CN-1157617-A | Heterobicyclic derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-08-20 | — | — | CN | disclosed |
| EP-0770079-A1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996001825-A1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046654-B2 | Urea compounds and their use as enzyme inhibitors | ACHE, GAA, GYS2 | IDO1 430/4885RAB9A 427/4885NPC1 305/4885 |
| US-20200140391-A1 | Processes for the Synthesis of Substituted Urea Compounds | GRHPR, REN, ODC1 | IDO1 2946/4885RAB9A 1634/4885NPC1 3091/4885 |
| US-20200255412-A1 | Imidazolecarboxamides and Their Use as FAAH Inhibitors | FAAH, FAAH2, AADAC | IDO1 201/4885RAB9A 2331/4885NPC1 609/4885 |
| US-11078163-B2 | Processes for the synthesis of substituted urea compounds | GRHPR, REN, ODC1 | IDO1 2946/4885RAB9A 1634/4885NPC1 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.