Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 8/20 | 0.59 |
| ▸ | PARP1 | P09874 | 4/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.53 |
| ▸ | GABRD | O14764 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160070 | 0.82 | TNKS (0.50) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL21510140 | 0.81 | TNKS (0.49) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL16915378 | 0.81 | HPGD (0.62) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL2483048 | 0.81 | KDM4E (0.56) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL30503392 | 0.81 | KDM4E (0.56) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL11508591 | 0.80 | HPGD (0.51) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL23334899 | 0.78 | TNKS (0.49) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL14243496 | 0.77 | AKR1B1 (0.61) | TNKSPARP1TNKS2KDM4ESMN1; SMN2 | |
| SCHEMBL29382214 | 0.77 | TNKS (0.51) | TNKSPARP1TNKS2PARP2HDAC6 | |
| SCHEMBL6949930 | 0.76 | KDM4E (0.55) | TNKSPARP1TNKS2PARP2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018045-B2 | 17-beta-hydroxywithanolides and use thereof in treating cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2024-06-25 | — | — | US | disclosed |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-01-18 | — | — | US | disclosed |
| WO-2023180463-A1 | ALBICIDIN DERIVATIVES, THEIR USE AND SYNTHESIS | Technische Universität Berlin (DE) | 2023-09-28 | — | — | WO | disclosed |
| US-11725010-B2 | Polyheterocyclic compounds as METTL3 inhibitors | STORM THERAPEUTICS LIMITED (GB) | 2023-08-15 | — | — | US | disclosed |
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-11-25 | — | — | US | disclosed |
| WO-2021085372-A1 | RESIN COMPOSITION, COMPOUND (Z), OPTICAL FILTER, AND USE THEREOF | JSR株式会社 | 2021-05-06 | — | — | WO | disclosed |
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-05 | — | — | US | disclosed |
| US-20200216430-A1 | CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2020-07-09 | — | — | US | disclosed |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-02-13 | — | — | US | disclosed |
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-8252936-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-08-28 | — | — | US | disclosed |
| US-8008499-B2 | Anabaseine derivatives, pharmaceutical compositions and methods of use thereof | CORNERSTONE THERAPEUTICS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100311773-A1 | NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutic, Inc. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7662965-B2 | 3-(3-(2,5-dichlorophenyl)furan-2-yl)methylene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine; antiinflammatory agent for inhibiting cytokine release from mammalian cells; treating CNS disorders; agonists of nicotinic acetylcholine receptors | CORNERSTONE THERAPEUTICS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090192175-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2009-07-30 | — | — | US | disclosed |
| US-20070232651-A1 | Novel anabaseine derivatives, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH | 2007-10-04 | — | — | US | disclosed |
| EP-1776161-A1 | COSMETIC OR DERMOPHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE UDP GLUCURONOSYL TRANSFERASE (UGT) ENZYMES INDUCER | Sederma S.A.S. (FR) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005102266-A1 | COSMETIC OR DERMOPHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE UDP GLUCURONOSYL TRANSFERASE (UGT) ENZYMES INDUCER | SEDERMA, SAS (FR) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232651-A1 | Novel anabaseine derivatives, pharmaceutical compositions and methods of use thereof | CHRNA7, CHRNA10, CHRNA5 | TNKS 1170/4885PARP1 1866/4885TNKS2 1345/4885 |
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | TNKS 3488/4885PARP1 2385/4885TNKS2 3043/4885 |
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | TNKS 1088/4885PARP1 1291/4885TNKS2 882/4885 |
| US-12018045-B2 | 17-beta-hydroxywithanolides and use thereof in treating cancer | HSD17B7, CYP17A1, HSD17B11 | TNKS 3288/4885PARP1 1348/4885TNKS2 2238/4885 |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | TNKS 1088/4885PARP1 1291/4885TNKS2 882/4885 |
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | TNKS 1088/4885PARP1 1291/4885TNKS2 882/4885 |
| US-20090192175-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CYP1B1 | TNKS 3340/4885PARP1 2735/4885TNKS2 3568/4885 |
| US-11725010-B2 | Polyheterocyclic compounds as METTL3 inhibitors | METTL3, DIMT1, TPMT | TNKS 633/4885PARP1 710/4885TNKS2 748/4885 |
| US-20100311773-A1 | NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CHRNA7, CHRNA10, CHRNA5 | TNKS 1170/4885PARP1 1866/4885TNKS2 1345/4885 |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SMURF2 | TNKS 2676/4885PARP1 3438/4885TNKS2 1087/4885 |
| US-20200216430-A1 | CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT | CYBB, NOX4, NOX3 | TNKS 730/4885PARP1 600/4885TNKS2 957/4885 |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | TNKS 3870/4885PARP1 2571/4885TNKS2 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.