SCHEMBL537382

SCHEMBL537382

c1ccc2c(c1)oc1ncccc12

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.72
ALDH1A1 P00352 6/20 0.72
MAPT P10636 6/20 0.46
NPC1 O15118 3/20 0.46
NCOA1 Q15788 1/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
EGFR P00533 4/20 0.44
IGF1R P08069 4/20 0.44
FLT4 P35916 4/20 0.44
KDR P35968 4/20 0.44
HPGD P15428 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
HSD17B10 Q99714 2/20 0.41
GLA P06280 1/20 0.41
CYP3A4 P08684 1/20 0.41
PGAM1 P18669 1/20 0.41
MAOA P21397 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29386410 1.00 KDM4E (0.72) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL15396798 0.91 KDM4E (0.62) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL30863308 0.84 KDM4E (1.00) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL2521419 0.84 KDM4E (1.00) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL30947375 0.84 KDM4E (1.00) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL11884983 0.84 KDM4E (0.55) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL15855373 0.82 KDM4E (0.53) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL15855349 0.82 KDM4E (0.53) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL15855351 0.82 KDM4E (0.53) KDM4EALDH1A1MAPTNPC1NCOA1
SCHEMBL15855350 0.82 KDM4E (0.53) KDM4EALDH1A1MAPTNPC1NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 243 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250250483-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2025-08-07 US claimed
US-20160093818-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-03-31 US claimed
US-20090076268-A1 Facile assembly of fused benzofuro-heterocycles JANSSEN PHARMACEUTICA N.V. (BE) 2009-03-19 US claimed
WO-2009035668-A1 FACILE ASSEMBLY OF FUSED BENZOFURO-HETEROCYCLES JANSSEN PHARMACEUTICA N.V. (BE) 2009-03-19 WO claimed
US-20260123268-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2026-04-30 US disclosed
US-12565613-B2 Quantum dots with donor-acceptor ligands SHOEI CHEMICAL INC. (JP) 2026-03-03 US disclosed
US-12448392-B2 Spiropiperidine derivatives CEPHALON LLC (US) 2025-10-21 US disclosed
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates CEPHALON LLC (US) 2025-10-14 US disclosed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 US disclosed
US-20250250483-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2025-08-07 US disclosed
US-20250126968-A1 Light-Emitting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2025-04-17 US disclosed
US-20240381687-A1 DISPLAY APPARATUS, DISPLAY MODULE, AND ELECTRONIC DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2024-11-14 US disclosed
WO-2006081973-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2006-08-10 WO disclosed
US-20060173026-A1 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents ACHILLION PHARMACEUTICALS, INC. 2006-08-03 US disclosed
WO-2006074317-A1 1-THIA-2,4A-DIAZA-CYCLOPENTA[B]NAPHTHALENE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS ACHILLION PHARMACEUTICALS, INC. (US) 2006-07-13 WO disclosed
EP-1664062-A1 ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS Achillion Pharmaceuticals, Inc. (US) 2006-06-07 EP disclosed
US-20060100215-A1 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents ACHILLION PHARMACEUTICALS, INC. 2006-05-11 US disclosed
US-20050075363-A1 Isothiazoloquinolones and related compounds as anti-infective agents ACHILLION PHARMACEUTICALS, INC. 2005-04-07 US disclosed
WO-2005019228-A1 ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS ACHILLION PHARMACEUTICALS, INC. (US) 2005-03-03 WO disclosed
US-5274100-A Process for the preparation of (3-fluoropyridin-2-yloxy)phenoxypropionic acids CIBA-GEIGY CORPORATION (US) 1993-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A KDM4E 1054/4885ALDH1A1 110/4885MAPT 3799/4885
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates FASN, CES1, FADS2 KDM4E 536/4885ALDH1A1 106/4885MAPT 3856/4885
US-12565613-B2 Quantum dots with donor-acceptor ligands HCCS, FDPS, FTH1 KDM4E 4066/4885ALDH1A1 125/4885MAPT 3930/4885
US-20050075363-A1 Isothiazoloquinolones and related compounds as anti-infective agents TOP1, IRF3, RECQL KDM4E 2795/4885ALDH1A1 2406/4885MAPT 4593/4885
US-20060173026-A1 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents TOP1, TOP2A, DNA2 KDM4E 3682/4885ALDH1A1 1042/4885MAPT 4670/4885
US-20260123268-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES GLRA1, LBR, GLRB KDM4E 4108/4885ALDH1A1 1949/4885MAPT 4497/4885
US-20250250483-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING DEVICE CRY1, CRY2, RPS23 KDM4E 3513/4885ALDH1A1 1497/4885MAPT 3617/4885
US-20090076268-A1 Facile assembly of fused benzofuro-heterocycles BICRA, DDC, DDT KDM4E 1620/4885ALDH1A1 739/4885MAPT 1787/4885
US-12448392-B2 Spiropiperidine derivatives FASN, FADS2, SCD5 KDM4E 3729/4885ALDH1A1 128/4885MAPT 4291/4885
US-20160093818-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device GPS1, AP1M1, AP3M1 KDM4E 2914/4885ALDH1A1 999/4885MAPT 3880/4885
US-20060100215-A1 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents RECQL, DNA2, REV1 KDM4E 2575/4885ALDH1A1 1263/4885MAPT 4329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.