Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168463 | 1.00 | LMNA (0.52) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| SCHEMBL168464 | 1.00 | LMNA (0.52) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| SCHEMBL28545652 | 0.98 | LMNA (0.50) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| 1,2-Dichlorobenzene SCHEMBL27641832 | 0.91 | FABP4 (0.46) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| SCHEMBL275598 | 0.84 | LMNA (0.64) | LMNAMAPK1ALDH1A1L3MBTL1POLB | |
| SCHEMBL28143820 | 0.83 | LMNA (0.43) | LMNAMAPK1ACP3ALDH1A1L3MBTL1 | |
| SCHEMBL21552683 | 0.83 | ESR1 (0.45) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| SCHEMBL124623 | 0.83 | ESR1 (0.45) | LMNAMAPK1ACP3ESR1ALDH1A1 | |
| SCHEMBL27719983 | 0.82 | ALDH1A1 (0.41) | LMNAMAPK1ALDH1A1FABP4FABP5 | |
| SCHEMBL959019 | 0.82 | CES2 (0.57) | LMNAACP3ESR1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985572-B2 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF SE (DE) | 2011-07-26 | — | — | US | claimed |
| EP-1599584-B1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF SE (DE) | 2009-07-01 | — | — | EP | claimed |
| US-20060259999-A1 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-16 | — | — | US | claimed |
| EP-1599584-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-30 | — | — | EP | claimed |
| WO-2004076655-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-10 | — | — | WO | claimed |
| US-4973750-A | Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols | SCHERING CORPORATION (US) | 1990-11-27 | — | — | US | claimed |
| US-10857517-B2 | Porous chiral materials and uses thereof | NANKAI UNIVERSITY (CN) | 2020-12-08 | — | — | US | disclosed |
| EP-3196185-B1 | ASYMMETRICAL HYDROGENATION REACTION OF KETONIC ACID COMPOUND | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECH CO LTD (CN) | 2019-06-12 | — | — | EP | disclosed |
| CN-109689667-A | Porous chiral material and use thereof | 南开大学 | 2019-04-26 | — | — | CN | disclosed |
| US-20170260119-A1 | Asymmetrical hydrogenation reaction of ketonic acid compound | ZHEJIANG JIUZHOU PHARMA SCIENCE&TECHNOLOGY CO LTD (CN) | 2017-09-14 | — | — | US | disclosed |
| US-20170260119-A1 | Asymmetrical hydrogenation reaction of ketonic acid compound | ZHEJIANG JIUZHOU PHARMA SCIENCE&TECHNOLOGY CO LTD (CN) | 2017-09-14 | — | — | US | disclosed |
| US-9718052-B2 | Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby | THE UNIVERSITY OF TOLEDO (US) | 2017-08-01 | — | — | US | disclosed |
| EP-3196185-A1 | ASYMMETRICAL HYDROGENATION REACTION OF KETONIC ACID COMPOUND | Zhejiang Jiuzhou Pharma Science & Technology Co., Ltd. (CN) | 2017-07-26 | — | — | EP | disclosed |
| EP-0200739-B1 | PREPARATION OF (THREO)-1-ARYL-2-ACYLAMIDO-3-FLUORO-1-PROPANOLS | SCHERING CORPORATION (US) | 1989-07-19 | — | — | EP | disclosed |
| US-4677214-A | Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols | SCHERING CORPORATION (US) | 1987-06-30 | — | — | US | disclosed |
| US-4582918-A | Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols | SCHERING CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| US-4297489-A | CEPHALOSPORINS | BRISTOL-MYERS COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4172196-A | CEPHALOSPORINS | BRISTOL-MYERS COMPANY (US) | 1979-10-23 | — | — | US | disclosed |
| US-4112228-A | BACTERICIDES | BRISTOL-MYERS COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-3985738-A | ANTIBACTERIAL AGENTS | BRISTOL-MYERS COMPANY (US) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260119-A1 | Asymmetrical hydrogenation reaction of ketonic acid compound | KHK, PKLR, BCKDK | LMNA 3213/4885MAPK1 1240/4885ACP3 1993/4885 |
| US-10857517-B2 | Porous chiral materials and uses thereof | ANXA7, XDH, OPRM1 | LMNA 219/4885MAPK1 1200/4885ACP3 2224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.