Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14954478 | 0.95 | ALDH1A1 (0.39) | ALDH1A1HPGDKDM4EHSD17B10P2RX7 | |
| SCHEMBL2185979 | 0.80 | P2RX7 (0.39) | ALDH1A1HPGDKDM4EHSD17B10P2RX7 | |
| Acetone SCHEMBL44217 | 0.77 | MAPK8 (0.37) | ALDH1A1KDM4EL3MBTL1TDP1LMNA | |
| Acetone SCHEMBL16337583 | 0.76 | MAPK8 (0.36) | ALDH1A1KDM4EL3MBTL1TDP1LMNA | |
| SCHEMBL4352598 | 0.73 | KDM4E (0.55) | ALDH1A1HPGDKDM4EHSD17B10TDP1 | |
| SCHEMBL4331088 | 0.73 | MAPK8 (0.37) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL1179791 | 0.72 | HTT (0.65) | ALDH1A1HPGDKDM4EHSD17B10P2RX7 | |
| Acetone SCHEMBL1019108 | 0.72 | NNMT (0.37) | KDM4EL3MBTL1TDP1LMNAMAPT | |
| Acetone SCHEMBL3359266 | 0.72 | DHODH (0.58) | ALDH1A1KDM4EP2RX7HTTL3MBTL1 | |
| Acetone SCHEMBL17732267 | 0.71 | NNMT (0.36) | KDM4EL3MBTL1TDP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130084561-A1 | BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | COULL JAMES M (US) | 2013-04-04 | — | — | US | disclosed |
| EP-2064348-B1 | RECEPTOR FAMILY PROFILING | ENSEMBLE THERAPEUTICS CORP (US) | 2012-02-08 | — | — | EP | disclosed |
| US-8071388-B2 | Compositions and methods for biodetection by nucleic acid-templated chemistry | ENSEMBLE THERAPEUTICS CORPORATION (US) | 2011-12-06 | — | — | US | disclosed |
| US-20110059458-A1 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY | ENSEMBLE THERAPEUTICS CORPORATION | 2011-03-10 | — | — | US | disclosed |
| US-20100159455-A1 | RECEPTOR FAMILY PROFILING | ENSEMBLE DISCOVERY | 2010-06-24 | — | — | US | disclosed |
| US-20090275142-A1 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | ENSEMBLE THERAPEUTICS CORPORATION | 2009-11-05 | — | — | US | disclosed |
| WO-2009105657-A1 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY | ENSEMBLE DISCOVERY CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |
| EP-2066813-A2 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | Ensemble Discovery Corporation (US) | 2009-06-10 | — | — | EP | disclosed |
| EP-2064348-A2 | RECEPTOR FAMILY PROFILING | Ensemble Discovery Corporation (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008054600-A2 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | ENSEMBLE DISCOVERY CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008036273-A2 | RECEPTOR FAMILY PROFILING | ENSEMBLE DISCOVERY CORPORATION (US) | 2008-03-27 | — | — | WO | disclosed |
| EP-1885891-A2 | BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | Ensemble Discovery Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| US-20070154899-A1 | Biodetection by nucleic acid-templated chemistry | ENSEMBLE THERAPEUTICS CORPORATION | 2007-07-05 | — | — | US | disclosed |
| WO-2006128138-A2 | BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | ENSEMBLE DISCOVERY CORPORTION (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275142-A1 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | POLRMT, NT5C3B, RNGTT | ALDH1A1 3803/4885HPGD 3447/4885KDM4E 3219/4885 |
| US-20110059458-A1 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY | POLRMT, POLN, POLM | ALDH1A1 2310/4885HPGD 1261/4885KDM4E 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.