Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365397 | 0.96 | ALDH1A1 (0.67) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL455924 | 0.82 | ALDH1A1 (0.69) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL924405 | 0.82 | ALDH1A1 (0.69) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL10338421 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL2778511 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL8447060 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL10338418 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL608774 | 0.80 | ALDH1A1 (1.00) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL1694716 | 0.79 | ALDH1A1 (0.66) | ALDH1A1RECQLHSD11B1MAPTHSD17B10 | |
| SCHEMBL29012562 | 0.78 | HSD11B1 (0.83) | ALDH1A1RECQLHSD11B1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2069452-A | — | — | None | — | — | JP | disclosed |
| JP-11001468-A | — | — | None | — | — | JP | disclosed |
| JP-11001467-A | — | — | None | — | — | JP | disclosed |
| US-8614360-B2 | Method for the preparation of [18F]fluoroalkylhalides | HAMMERSMITH IMANET LIMITED (GB) | 2013-12-24 | — | — | US | disclosed |
| EP-1960324-B1 | METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES | HAMMERSMITH IMANET LTD (GB) | 2012-02-08 | — | — | EP | disclosed |
| US-20090247793-A1 | METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES | HAMMERSMITH IMANET LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| EP-1960324-A1 | METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES | Hammersmith Imanet Limited (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067074-A1 | METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES | HAMMERSMITH IMANET LIMITED (GB) | 2007-06-14 | — | — | WO | disclosed |
| JP-H111467-A | PRODUCTION OF DIIODOMETHYL-P-TOLUYLSULFONE | MITSUI CHEM INC | 1999-01-06 | — | — | JP | disclosed |
| JP-H111468-A | PRODUCTION OF DIIODOMETHYL-P-TOLUYLSULFONE | MITSUI CHEM INC | 1999-01-06 | — | — | JP | disclosed |
| JP-H0269452-A | PRODUCTION OF DIIODIDOMETHYL-P-TOLYLSULFONE | MITSUI TOATSU CHEM INC | 1990-03-08 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247793-A1 | METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES | HAGH, FAH, FTO | ALDH1A1 279/4885RECQL 2642/4885HSD11B1 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.